of the computational resources is very good and it even includes a letter specifically mentioning the level of compute power the PI will receive. Weaknesses * None. Protections for Human Subjects: Not Applicable (No Human Subjects) Vertebrate Animals: Not Applicable (No Vertebrate Animals) Biohazards: Not Applicable (No Biohazards) Resource Sharing Plans: Acceptable Budget and Period of Support: Recommend as Requested

Public Health Relevance

Antimicrobial peptides are naturally produced by a wide range of organisms, including humans, as defense against microbial infection. However, their mechanism of action is not well understood. There is broad consensus that they attack the bacterial membrane, but no reliable method is available for predicting the efficacy of a given peptide. This work aims to understand how peptides stabilize pores in biological membranes, using a combination of theoretical methods guided and tested by experimental measurements. Success in this effort could open the door to the design of novel antibiotics, which are sorely needed given the growth of microbial resistance to currently used antibiotics.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM117146-03
Application #
9405028
Study Section
Biochemistry and Biophysics of Membranes Study Section (BBM)
Program Officer
Ainsztein, Alexandra M
Project Start
2016-01-01
Project End
2019-12-31
Budget Start
2018-01-01
Budget End
2018-12-31
Support Year
3
Fiscal Year
2018
Total Cost
Indirect Cost
Name
City College of New York
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
603503991
City
New York
State
NY
Country
United States
Zip Code
10036
Lipkin, Richard; Lazaridis, Themis (2017) Computational prediction of the optimal oligomeric state for membrane-inserted ?-barrels of protegrin-1 and related mutants. J Pept Sci 23:334-345
Lipkin, Richard; Pino-Angeles, Almudena; Lazaridis, Themis (2017) Transmembrane Pore Structures of ?-Hairpin Antimicrobial Peptides by All-Atom Simulations. J Phys Chem B 121:9126-9140
Lipkin, Richard; Lazaridis, Themis (2017) Computational studies of peptide-induced membrane pore formation. Philos Trans R Soc Lond B Biol Sci 372:
Lazaridis, Themis; Hummer, Gerhard (2017) Classical Molecular Dynamics with Mobile Protons. J Chem Inf Model 57:2833-2845