A 1260 II UHPLC with 8-column switching valve, a quaternary pump, autosampler, high sensitivity diode array (DAD) and 8 column switching valve is requested to replace an 18-year old Waters HPLC, which cannot keep up with our current demands in the research area of halogenation reagents and conditions that include exploring stereoselective halogenation approaches and F18. The quote from the manufacturer is $ 59,703.38

Public Health Relevance

In the first year of the NIH award my group produced six papers and a five conference presentations., described in our first year report, last October. Since then, we have published--in only 7 months--a total of six new papers in top-rated journals, including one JACS, one Angewandte, one ACS Catalysis and one Organic Letters (all listed below). We have also submitted a patent application for a technology described in our JACS paper (publication #6). The fast-paced chemistry that we are engaged on has overrun the limits of our current HPLC Waters unit, which was bought in 2004 (18 years ago). Especially, now that we are interested in exploring the enantioselective applications of our halogenation protocols we want to purchase an Agilent HPLC system. It is a 1260 II UHPLC with 8-column switching valve, a quaternary pump, autosampler, high sensitivity diode array (DAD) and 8 column switching valve. This unit delivers pressures up to 600 bar. Its pulse-free, stable and well- mixed gradients ensure higher sensitivity and more reliable results . The unit has access to up to four solvents, giving great flexibility in automated solvent blending for a wide range of research applications. The InfinityLab Poroshell 120 columns provide fast, rugged, high-resolution separations. High-sensitivity flow cells for the diode array detector will allow us to detect the weakest sample concentrations.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
3R01GM121660-02S1
Application #
9707486
Study Section
Program Officer
Lees, Robert G
Project Start
2016-12-06
Project End
2021-11-30
Budget Start
2017-12-01
Budget End
2018-11-30
Support Year
2
Fiscal Year
2018
Total Cost
Indirect Cost
Name
University of Louisville
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
057588857
City
Louisville
State
KY
Country
United States
Zip Code
40292
Liang, Shengzong; Hammond, Gerald B; Xu, Bo (2018) Metal-free Regioselective Hydrochlorination of Unactivated Alkenes via a Combined Acid Catalytic System. Green Chem 20:680-684
Zeng, Xiaojun; Liu, Shiwen; Hammond, Gerald B et al. (2018) Hydrogen-Bonding-Assisted Brønsted Acid and Gold Catalysis: Access to Both (E)- and (Z)-1,2-Haloalkenes via Hydrochlorination of Haloalkynes. ACS Catal 8:904-909
Ebule, Rene; Hammond, Gerald B; Xu, Bo (2018) Metal-free Chlorothiolation of Alkenes using HCl and Sulfoxides. European J Org Chem 2018:4705-4708
Zeng, Xiaojun; Li, Junling; Ng, Chin K et al. (2018) (Radio)fluoroclick Reaction Enabled by a Hydrogen-Bonding Cluster. Angew Chem Int Ed Engl 57:2924-2928
Sedgwick, Daniel M; López, Inés; Román, Raquel et al. (2018) Metal-Free and User-Friendly Regioselective Hydroxyfluorination of Olefins. Org Lett 20:2338-2341
Zeng, Xiaojun; Lu, Zhichao; Liu, Shiwen et al. (2017) Metal-free, Regio-, and Stereo-Controlled Hydrochlorination and Hydrobromination of Ynones and Ynamides. J Org Chem 82:13179-13187
Zeng, Xiaojun; Liu, Shiwen; Hammond, Gerald B et al. (2017) Divergent Regio- and Stereoselective Gold-catalyzed Synthesis of ?-Fluorosulfones and ?-Fluorovinylsulfones from Alkynylsulfones. Chemistry 23:11977-11981
Liang, Shengzong; Barrios, Francis J; Okoromoba, Otome E et al. (2017) Bromofluorination of Unsaturated Compounds using DMPU/HF as a Fluorinating Reagent. J Fluor Chem 203:136-139
Zeng, Xiaojun; Lu, Zhichao; Liu, Shiwen et al. (2017) Gold-catalyzed Fluorination of Alkynyl Esters and Ketones: Efficient Access to Fluorinated 1,3-Dicarbonyl Compounds. Adv Synth Catal 359:4062-4066
Liang, Shengzong; Ebule, Rene; Hammond, Gerald B et al. (2017) A Chlorinating Reagent Yields Vinyl Chlorides with High Regioselectivity under Heterogeneous Gold Catalysis. Org Lett 19:4524-4527

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