The goal of this proposal is to investigate the role of a novel Telomere associated protein that we termed TZAP in telomere homeostasis. Telomeres are essential nucleoprotein structures that cap chromosome ends. Alterations in telomere function are associated with various human diseases including cancer, premature aging, dyskeratosis congenita, aplastic anemia, and idiopathic pulmonary fibrosis. Our preliminary data show that TZAP is a novel telomere specific binding protein that is involved in telomere length homoeostasis. Several questions remain to be addressed to define the role of this novel telomere associated protein in telomere homeostasis. To address this questions, we have devised a research proposal that will define the mechanism of TZAP binding to telomeres, its role on telomere length regulation and the impact of its depletion in respect to genome stability and tissue homoeostasis.

Public Health Relevance

We have discovered a novel telomere associated protein that we termed Telomeric Zinc Finger Associated Protein (TZAP). In this proposal we will address the role of TZAP in telomere homeostasis and genome stability.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM122987-03
Application #
9644065
Study Section
Molecular Genetics A Study Section (MGA)
Program Officer
Ainsztein, Alexandra M
Project Start
2017-05-01
Project End
2021-02-28
Budget Start
2019-03-01
Budget End
2020-02-29
Support Year
3
Fiscal Year
2019
Total Cost
Indirect Cost
Name
Scripps Research Institute
Department
Type
DUNS #
781613492
City
La Jolla
State
CA
Country
United States
Zip Code
92037
Li, Julia Su Zhou; Denchi, Eros Lazzerini (2018) How stem cells keep telomeres in check. Differentiation 100:21-25
Vilas, Caroline K; Emery, Lara E; Denchi, Eros Lazzerini et al. (2018) Caught with One's Zinc Fingers in the Genome Integrity Cookie Jar. Trends Genet 34:313-325