The proposed study will utilize existing data from 7 major longitudinal growth studies in which more than 2000 individuals were enrolled; some of these records extend for periods longer than 50 years. Use will be made also of existing cross-sectional data from some very large kindreds, from NCHS surveys, from USAF surveys and from studies in which anthropometric and densitometric data have been obtained. In addition, further serial data will be obtained from juvenile and adult participants in the Fels Longitudinal Study, including some additional variables relating to apolipoproteins and impedance. The long-term aims are to achieve more complete understanding of the natural history of body fatness and the extent to which tracking occurs in fatness and associated risk factors. This is relevant to the timing of preventive measures. Some planned analyses relate to fat patterning and probable changes with age in the associations between body fatness and frame size. Pubescent changes in body composition and the relationships between risk factors during pubescence and in adulthood will be examined. Some analyses will relate to the potential use of frame size in the interpretation of observed weight. Appropriate measures of frame size will be sought that are highly correlated with weight, but independent of fat. Reference data will be provided if appropriate. It is well-known that the management of obesity is often inefficient, if judged over long intervals. To some extent, this may reflect application of a single treatment mode to a heterogeneous group of conditions. The effective categorization of obesity requires data of many types and is unlikely to be achieved in a single study. It is expected, however, that the proposed research will provide useful findings in regard to categories based on anthropometric and body composition data. Associated with this aim correlations between impedance measurements and lean body mass will be examined and equations developed that provide estimates of body composition from anthropometric data. Other planned analyses concern associations between risk factors, e.g., blood pressure, plasma lipids, and variations in the amounts and types of body fatness and in adipocyte size. Attempts will be made to """"""""separate"""""""" the genetic and cultural determinants of body fatness by applying path analysis to sets of data from large numbers of nuclear families.

Project Start
1977-07-01
Project End
1988-11-30
Budget Start
1987-12-01
Budget End
1988-11-30
Support Year
11
Fiscal Year
1988
Total Cost
Indirect Cost
Name
Wright State University
Department
Type
Schools of Medicine
DUNS #
City
Dayton
State
OH
Country
United States
Zip Code
45435
(2017) 24th European Congress on Obesity (ECO2017), Porto, Portugal, May 17-20, 2017: Abstracts. Obes Facts 10 Suppl 1:1-274
Chu, Audrey Y; Deng, Xuan; Fisher, Virginia A et al. (2017) Multiethnic genome-wide meta-analysis of ectopic fat depots identifies loci associated with adipocyte development and differentiation. Nat Genet 49:125-130
Froehle, Andrew W; Grannis, Kimberly A; Sherwood, Richard J et al. (2017) Relationships Between Age at Menarche, Walking Gait Base of Support, and Stance Phase Frontal Plane Knee Biomechanics in Adolescent Girls. PM R 9:444-454
Whitaker, K M; Choh, A C; Lee, M et al. (2016) Sex differences in the rate of abdominal adipose accrual during adulthood: the Fels Longitudinal Study. Int J Obes (Lond) 40:1278-85
Lu, Juan; Shin, Yongyun; Yen, Miao-Shan et al. (2016) Peak Bone Mass and Patterns of Change in Total Bone Mineral Density and Bone Mineral Contents From Childhood Into Young Adulthood. J Clin Densitom 19:180-91
Duren, Dana L; Nahhas, Ramzi W; Sherwood, Richard J (2015) Do Secular Trends in Skeletal Maturity Occur Equally in Both Sexes? Clin Orthop Relat Res 473:2559-67
Šešelj, Maja; Duren, Dana L; Sherwood, Richard J (2015) Heritability of the Human Craniofacial Complex. Anat Rec (Hoboken) 298:1535-47
Johnson, William (2015) Analytical strategies in human growth research. Am J Hum Biol 27:69-83
Chumlea, W M Cameron (2014) Response to the letter to the editor: ""Frailty consensus: a call to action"". J Am Med Dir Assoc 15:142-3
Froehle, Andrew W; Laughlin, Richard T; Teel 2nd, Donovan D et al. (2014) Excess body weight loss is associated with nonpathological gait patterns in women 4 to 5 years after bariatric surgery. Obes Surg 24:253-9

Showing the most recent 10 out of 85 publications