Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project (R01)
Project #
5R01HD014198-10
Application #
3312519
Study Section
General Medicine A Subcommittee 2 (GMA)
Project Start
1979-08-01
Project End
1988-08-31
Budget Start
1988-01-01
Budget End
1988-08-31
Support Year
10
Fiscal Year
1988
Total Cost
Indirect Cost

  Institution

Name
University of Texas Health Science Center Houston
Department
Type
Schools of Medicine
DUNS #
City
Houston
State
TX
Country
United States
Zip Code
77225

  Publications

Little, J M; Drake, R R; Vonk, R et al. (1995) Characterization of human liver microsomal UDP-glycosyltransferases using photoaffinity analogs. J Pharmacol Exp Ther 273:1551-9
Battaglia, E; Elass, A; Drake, R R et al. (1995) Characterization of a new class of inhibitors of the recombinant human liver UDP-glucuronosyltransferase, UGT1*6. Biochim Biophys Acta 1243:9-14
Radominska, A; Little, J M; Lester, R et al. (1994) Bile acid glucuronidation by rat liver microsomes and cDNA-expressed UDP-glucuronosyltransferases. Biochim Biophys Acta 1205:75-82
Radominska, A; Paul, P; Treat, S et al. (1994) Photoaffinity labeling for evaluation of uridinyl analogs as specific inhibitors of rat liver microsomal UDP-glucuronosyltransferases. Biochim Biophys Acta 1205:336-45
Radominska, A; Berg, C; Treat, S et al. (1994) Characterization of UDP-glucuronic acid transport in rat liver microsomal vesicles with photoaffinity analogs. Biochim Biophys Acta 1195:63-70
Radominska, A; Treat, S; Little, J (1993) Bile acid metabolism and the pathophysiology of cholestasis. Semin Liver Dis 13:219-34
Radominska, A; Little, J; Pyrek, J S et al. (1993) A novel UDP-Glc-specific glucosyltransferase catalyzing the biosynthesis of 6-O-glucosides of bile acids in human liver microsomes. J Biol Chem 268:15127-35
Panfil, I; Lehman, P A; Zimniak, P et al. (1992) Biosynthesis and chemical synthesis of carboxyl-linked glucuronide of lithocholic acid. Biochim Biophys Acta 1126:221-8
Zimniak, P; Ziller 3rd, S A; Panfil, I et al. (1992) Identification of an anion-transport ATPase that catalyzes glutathione conjugate-dependent ATP hydrolysis in canalicular plasma membranes from normal rats and rats with conjugated hyperbilirubinemia (GY mutant). Arch Biochem Biophys 292:534-8
Radominska, A; Little, J M; Lester, R et al. (1992) Hepatic metabolism of 3-oxoandrost-4-ene-17 beta-carboxylic acid in the adult rat: formation of carboxyl-linked glucuronides both in vivo and in vitro. Steroids 57:328-34

Showing the most recent 10 out of 40 publications