Chronic lung disease in children is a serious problem;the two-year mortality is 35% on full contemporary medical and pharmacological management. Recovery by growth and remodeling occurs but is limited by impaired gas exchange and pulmonary hypertension. Lung transplantation is the only definitive treatment, and is feasible but rarely practiced. One of the major limitations is the lack of an artificial lung bridge to transplantation. Over three decades we have developed the extracorporeal artificial lung (ECMO) from laboratory to clinical research to mature clinical practice. This research has been supported by the current grant (HD 15434) since 1981. This is a continued renewal application for that grant. ECMO is effective for acute respiratory failure but because of complexity is not applicable to chronic respiratory failure bridging to lung transplantation in children. Over the lat decade we addressed this problem for adult respiratory failure resulting in the development of an implantable artificial lung which is now routinely used successfully as a bridge to transplantation. The goal of the proposed research is to develop an implantable artificial lung for children which can serve as a bridge to recovery or transplantation.
The diverse group of conditions described as chronic lung disease in infants and children is a serious problem. Recovery by growth and remodeling occurs but is limited by impaired gas exchange and pulmonary hypertension. Lung transplantation is the only definitive treatment, and is feasible but rarely practiced. One of the major limitations i the lack of an artificial lung bridge to recovery or transplantation. ECMO is effective for acute respiratory failure but, because of complexity, is not applicable to chronic respiratory failure in children. Over the last decade we developed the technique of pulmonary artery to left atrium (PA-LA) attachment of an implantable artificial lung. This technique is now used successfully as a bridge to recovery in acute lung disease or transplantation in chronic lung disease in adults. The goal of the proposed research is to develop implantable artificial lung technology for children which can serve as a bridge to recovery or transplantation.
|Sun, Liqun; Kaesler, Andreas; Fernando, Piyumindri et al. (2017) CO2 clearance by membrane lungs. Perfusion :267659117736379|
|Alghanem, Fares; Bryner, Benjamin S; Jahangir, Emilia M et al. (2017) Pediatric Artificial Lung: A Low-Resistance Pumpless Artificial Lung Alleviates an Acute Lamb Model of Increased Right Ventricle Afterload. ASAIO J 63:223-228|
|Trahanas, John M; Alghanem, Fares; Ceballos-Muriel, Catalina et al. (2017) Development of a Model of Pediatric Lung Failure Pathophysiology. ASAIO J 63:216-222|
|Fernando, Uditha Piyumindri; Thompson, Alex J; Potkay, Joseph et al. (2017) A Membrane Lung Design Based on Circular Blood Flow Paths. ASAIO J 63:637-643|
|Church, Joseph T; Alghanem, Fares; Deatrick, Kristopher B et al. (2017) Normothermic Ex Vivo Heart Perfusion: Effects of Live Animal Blood and Plasma Cross Circulation. ASAIO J 63:766-773|
|Witer, Lucas J; Howard, Ryan A; Trahanas, John M et al. (2016) Large Animal Model of Pumpless Arteriovenous Extracorporeal CO? Removal Using Room Air via Subclavian Vessels. ASAIO J 62:110-3|
|Trahanas, John M; Kolobow, Mary Anne; Hardy, Mark A et al. (2016) ""Treating Lungs"": The Scientific Contributions of Dr. Theodor Kolobow. ASAIO J 62:203-10|
|Wo, Yaqi; Li, Zi; Brisbois, Elizabeth J et al. (2015) Origin of Long-Term Storage Stability and Nitric Oxide Release Behavior of CarboSil Polymer Doped with S-Nitroso-N-acetyl-D-penicillamine. ACS Appl Mater Interfaces 7:22218-27|
|Brisbois, Elizabeth J; Davis, Ryan P; Jones, Anna M et al. (2015) Reduction in Thrombosis and Bacterial Adhesion with 7 Day Implantation of S-Nitroso-N-acetylpenicillamine (SNAP)-Doped Elast-eon E2As Catheters in Sheep. J Mater Chem B 3:1639-1645|
|Alghanem, Fares; Davis, Ryan P; Bryner, Benjamin S et al. (2015) The Implantable Pediatric Artificial Lung: Interim Report on the Development of an End-Stage Lung Failure Model. ASAIO J 61:453-8|
Showing the most recent 10 out of 60 publications