Chronic lung disease in children is a serious problem;the two-year mortality is 35% on full contemporary medical and pharmacological management. Recovery by growth and remodeling occurs but is limited by impaired gas exchange and pulmonary hypertension. Lung transplantation is the only definitive treatment, and is feasible but rarely practiced. One of the major limitations is the lack of an artificial lung bridge to transplantation. Over three decades we have developed the extracorporeal artificial lung (ECMO) from laboratory to clinical research to mature clinical practice. This research has been supported by the current grant (HD 15434) since 1981. This is a continued renewal application for that grant. ECMO is effective for acute respiratory failure but because of complexity is not applicable to chronic respiratory failure bridging to lung transplantation in children. Over the lat decade we addressed this problem for adult respiratory failure resulting in the development of an implantable artificial lung which is now routinely used successfully as a bridge to transplantation. The goal of the proposed research is to develop an implantable artificial lung for children which can serve as a bridge to recovery or transplantation.

Public Health Relevance

The diverse group of conditions described as chronic lung disease in infants and children is a serious problem. Recovery by growth and remodeling occurs but is limited by impaired gas exchange and pulmonary hypertension. Lung transplantation is the only definitive treatment, and is feasible but rarely practiced. One of the major limitations i the lack of an artificial lung bridge to recovery or transplantation. ECMO is effective for acute respiratory failure but, because of complexity, is not applicable to chronic respiratory failure in children. Over the last decade we developed the technique of pulmonary artery to left atrium (PA-LA) attachment of an implantable artificial lung. This technique is now used successfully as a bridge to recovery in acute lung disease or transplantation in chronic lung disease in adults. The goal of the proposed research is to develop implantable artificial lung technology for children which can serve as a bridge to recovery or transplantation.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project (R01)
Project #
5R01HD015434-31
Application #
8657461
Study Section
Special Emphasis Panel (ZRG1-SBIB-V (82))
Program Officer
Raju, Tonse N
Project Start
1980-08-01
Project End
2017-04-30
Budget Start
2014-05-01
Budget End
2015-04-30
Support Year
31
Fiscal Year
2014
Total Cost
$508,666
Indirect Cost
$152,755
Name
University of Michigan Ann Arbor
Department
Surgery
Type
Schools of Medicine
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
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