Abstract

In this proposal, the investigators focus on maternal lipid insulin sensitivity, defined as the ability of insulin to suppress whole body lipolysis as estimated from changes in free fatty acid (FFA) concentration and glycerol turnover, in order to evaluate possible mechanisms for changes in maternal body composition and fetal growth observed during the last funding period.
The specific aims are to: 1) evaluate the longitudinal changes in maternal lipid insulin sensitivity prior to and during pregnancy in lean and obese women with normal glucose tolerance (CTL) and gestational diabetes (GDM) and 2) determine if alterations in insulin signaling pathways in adipose tissue are the mechanism(s) underlying changes in maternal lipid insulin sensitivity during pregnancy.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project (R01)
Project #
5R01HD022965-13
Application #
6387530
Study Section
Human Embryology and Development Subcommittee 1 (HED)
Program Officer
Ilekis, John V
Project Start
1987-06-02
Project End
2003-06-30
Budget Start
2001-07-01
Budget End
2002-06-30
Support Year
13
Fiscal Year
2001
Total Cost
$224,792
Indirect Cost

  Institution

Name
Case Western Reserve University
Department
Obstetrics & Gynecology
Type
Schools of Medicine
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106

  Publications

Berggren, E K; O'Tierney-Ginn, P; Lewis, S et al. (2017) Variations in resting energy expenditure: impact on gestational weight gain. Am J Obstet Gynecol 217:445.e1-445.e6
Catalano, Patrick M; Shankar, Kartik (2017) Obesity and pregnancy: mechanisms of short term and long term adverse consequences for mother and child. BMJ 356:j1
Ma, Ronald Ching Wan; Schmidt, Maria Ines; Tam, Wing Hung et al. (2016) Clinical management of pregnancy in the obese mother: before conception, during pregnancy, and post partum. Lancet Diabetes Endocrinol 4:1037-1049
Yang, Xiaohua; Li, Ming; Haghiac, Maricela et al. (2016) Causal relationship between obesity-related traits and TLR4-driven responses at the maternal-fetal interface. Diabetologia 59:2459-2466
Berggren, Erica K; Presley, Larraine; Amini, Saeid B et al. (2015) Are the metabolic changes of pregnancy reversible in the first year postpartum? Diabetologia 58:1561-8
Catalano, P; deMouzon, S H (2015) Maternal obesity and metabolic risk to the offspring: why lifestyle interventions may have not achieved the desired outcomes. Int J Obes (Lond) 39:642-9
Lassance, Luciana; Haghiac, Maricela; Leahy, Patrick et al. (2015) Identification of early transcriptome signatures in placenta exposed to insulin and obesity. Am J Obstet Gynecol 212:647.e1-11
O'Tierney-Ginn, Perrie; Presley, Larraine; Myers, Stephen et al. (2015) Placental growth response to maternal insulin in early pregnancy. J Clin Endocrinol Metab 100:159-65
Yang, Xiaohua; Haghiac, Maricela; Glazebrook, Patricia et al. (2015) Saturated fatty acids enhance TLR4 immune pathways in human trophoblasts. Hum Reprod 30:2152-9
Lassance, Luciana; Haghiac, Maricela; Minium, Judi et al. (2015) Obesity-induced down-regulation of the mitochondrial translocator protein (TSPO) impairs placental steroid production. J Clin Endocrinol Metab 100:E11-8

Showing the most recent 10 out of 45 publications