The period before birth is the final frontier of investigation in human health and development. Interest in fetal origins of childhood and adult well-being has increased exponentially in recent years. We have been documenting normative development of the fetus for the past 16 years under the auspices of this award. Our goals have, and continue to be, threefold. These include: characterizing normal patterns of development of fetal neurobehavioral and physiological functioning during gestation in healthy, low risk pregnancies (Ontogeny);determining how maternal mediators, both psychological and physiological, affect the course of antenatal development (Maternal Influences), and evaluating within and cross-domain continuity in function from prenatal to postnatal development within individuals as a means of understanding the origins of individual differences (Prediction). This project period will focus on further defining the effects of evoked fetal reactivity on maternal function, and evoked maternal reactivity on fetal functioning. This endeavor was generated by findings in the current project period that revealed temporal, bidirectional linkages within the maternal-fetal pair. Two prenatal studies are proposed. The first (n = 52) examines the capacity of an evoked fetal response generated by auditory stimulus presentation to elicit a maternal physiological response at three gestational periods (24, 30, and 36 weeks). The second (n = 108) evaluates fetal responsivity to maternal arousal evoked within a pregnancy specific context at four gestational periods (18, 24, 30, and 36 weeks). Both studies include indicators of maternal autonomic (heart rate, vagal tone, skin conductance, respiration) and neurohormonal (salivary cortisol) activation;fetal measures focus on heart rate and its patterning, motor activity, and the relation between the two. Pairs will be followed at 5 months postnatal age to determine how features of prenatal maternal-fetal synchrony and responsiveness to one another contribute to the unfolding maternal-infant relationship, as measured by the degree of behavioral and physiological synchrony during an undisturbed, baseline interactive period and a still-face condition designed to disrupt the temporal regulatory process between the pair. This project will further our understanding of the maternal factors that impinge, positively or negatively, on the developing fetus and the origins of the earliest relationship.

Public Health Relevance

There is tremendous recent interest in characterizing how development proceeds before birth and its implications for later life. In this study we will investigate how maternal physiology and emotions affect the development of the fetus and how the developing fetus may affect the pregnant woman. We will apply this information to understanding how mothers interact with their infants during their first year of life.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project (R01)
Project #
5R01HD027592-18
Application #
7786991
Study Section
Biobehavioral Mechanisms of Emotion, Stress and Health Study Section (MESH)
Program Officer
Kau, Alice S
Project Start
1991-08-01
Project End
2013-02-28
Budget Start
2010-03-01
Budget End
2011-02-28
Support Year
18
Fiscal Year
2010
Total Cost
$409,151
Indirect Cost
Name
Johns Hopkins University
Department
Miscellaneous
Type
Schools of Public Health
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21218
DiPietro, J A; Voegtline, K M (2017) The gestational foundation of sex differences in development and vulnerability. Neuroscience 342:4-20
Voegtline, Kristin M; Costigan, Kathleen A; DiPietro, Janet A (2017) Maternal salivary testosterone in pregnancy and fetal neuromaturation. Dev Psychobiol 59:822-831
Michelson, Nicole; Riis, Jenna L; Johnson, Sara B (2016) Subjective Social Status and Psychological Distress in Mothers of Young Children. Matern Child Health J 20:2019-29
Voegtline, Kristin M; Costigan, Kathleen A; Henderson, Janice L et al. (2016) Fetal heart rate and motor development in overweight and obese pregnant women. Int J Gynaecol Obstet 133:103-7
Moore, Ginger A; Quigley, Kelsey M; Voegtline, Kristin M et al. (2016) Don't worry, be (moderately) happy: Mothers' anxiety and positivity during pregnancy independently predict lower mother-infant synchrony. Infant Behav Dev 42:60-8
DiPietro, Janet A; Costigan, Kathleen A; Voegtline, Kristin M (2015) STUDIES IN FETAL BEHAVIOR: REVISITED, RENEWED, AND REIMAGINED. Monogr Soc Res Child Dev 80:vii;1-94
Riis, Jenna L; Granger, Douglas A; DiPietro, Janet A et al. (2015) Salivary cytokines as a minimally-invasive measure of immune functioning in young children: correlates of individual differences and sensitivity to laboratory stress. Dev Psychobiol 57:153-67
DiPietro, Janet A; Goldshore, Matthew A; Kivlighan, Katie T et al. (2015) The ups and downs of early mothering. J Psychosom Obstet Gynaecol 36:94-102
DiPietro, Janet A; Davis, Meghan F; Costigan, Kathleen A et al. (2014) Fetal heart rate and motor activity associations with maternal organochlorine levels: results of an exploratory study. J Expo Sci Environ Epidemiol 24:474-81
Voegtline, K M; Costigan, K A; Kivlighan, K T et al. (2013) Sex-specific associations of maternal prenatal testosterone levels with birth weight and weight gain in infancy. J Dev Orig Health Dis 4:280-4

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