This is a resubmission of a competing continuation of a five year project which assessed cognitive deterioration in adolescents with insulin dependent diabetes mellitus (IDDM) during experimentally induced mild hypoglycemia, assessed the relationship between CBF (cerebral blood flow), prior glycemic control and hormonal counter-regulation to degree of cognitive impairment. The current submission seeks to extend this work to Aunderstand the mechanism that causes many children with IDDM to exhibit cognitive deterioration during mild hypoglycemia, and to assess a possible therapeutic strategy to prevent this from happening.@ Investigators seek to Aunravel the effects of the glycemic plateau and to verify the experimental insulin-glucose paradigms used to assess responses to hypoglycemia.
|Garg, Meena; Thamotharan, Manikkavasagar; Becker, Dorothy J et al. (2014) Adolescents with clinical type 1 diabetes display reduced red blood cell glucose transporter isoform 1 (GLUT1). Pediatr Diabetes 15:511-8|
|Ryan, Christopher; Gurtunca, Nursen; Becker, Dorothy (2005) Hypoglycemia: a complication of diabetes therapy in children. Pediatr Clin North Am 52:1705-33|
|Ryan, Christopher M; Dulay, Daisy; Suprasongsin, Chittiwat et al. (2002) Detection of symptoms by adolescents and young adults with type 1 diabetes during experimental induction of mild hypoglycemia: role of hormonal and psychological variables. Diabetes Care 25:852-8|
|Becker, D J; Ryan, C M (2000) Hypoglycemia: a complication of diabetes therapy in children. Trends Endocrinol Metab 11:198-202|
|Ryan, C M; Becker, D J (1999) Hypoglycemia in children with type 1 diabetes mellitus. Risk factors, cognitive function, and management. Endocrinol Metab Clin North Am 28:883-900|
|Jarjour, I T; Ryan, C M; Becker, D J (1995) Regional cerebral blood flow during hypoglycaemia in children with IDDM. Diabetologia 38:1090-5|