This is a resubmission of a competing continuation of a five year project which assessed cognitive deterioration in adolescents with insulin dependent diabetes mellitus (IDDM) during experimentally induced mild hypoglycemia, assessed the relationship between CBF (cerebral blood flow), prior glycemic control and hormonal counter-regulation to degree of cognitive impairment. The current submission seeks to extend this work to Aunderstand the mechanism that causes many children with IDDM to exhibit cognitive deterioration during mild hypoglycemia, and to assess a possible therapeutic strategy to prevent this from happening.@ Investigators seek to Aunravel the effects of the glycemic plateau and to verify the experimental insulin-glucose paradigms used to assess responses to hypoglycemia.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project (R01)
Project #
2R01HD029487-06A1
Application #
6012719
Study Section
Behavioral Medicine Study Section (BEM)
Program Officer
Malozowski, Saul N
Project Start
1993-07-20
Project End
2004-04-30
Budget Start
1999-06-20
Budget End
2000-06-18
Support Year
6
Fiscal Year
1999
Total Cost
Indirect Cost
Name
Children's Hosp Pittsburgh/Upmc Health Sys
Department
Type
DUNS #
044304145
City
Pittsburgh
State
PA
Country
United States
Zip Code
15224
Garg, Meena; Thamotharan, Manikkavasagar; Becker, Dorothy J et al. (2014) Adolescents with clinical type 1 diabetes display reduced red blood cell glucose transporter isoform 1 (GLUT1). Pediatr Diabetes 15:511-8
Ryan, Christopher; Gurtunca, Nursen; Becker, Dorothy (2005) Hypoglycemia: a complication of diabetes therapy in children. Pediatr Clin North Am 52:1705-33
Ryan, Christopher M; Dulay, Daisy; Suprasongsin, Chittiwat et al. (2002) Detection of symptoms by adolescents and young adults with type 1 diabetes during experimental induction of mild hypoglycemia: role of hormonal and psychological variables. Diabetes Care 25:852-8
Becker, D J; Ryan, C M (2000) Hypoglycemia: a complication of diabetes therapy in children. Trends Endocrinol Metab 11:198-202
Ryan, C M; Becker, D J (1999) Hypoglycemia in children with type 1 diabetes mellitus. Risk factors, cognitive function, and management. Endocrinol Metab Clin North Am 28:883-900
Jarjour, I T; Ryan, C M; Becker, D J (1995) Regional cerebral blood flow during hypoglycaemia in children with IDDM. Diabetologia 38:1090-5