Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project (R01)
Project #
5R01HD034380-02
Application #
2609137
Study Section
Mammalian Genetics Study Section (MGN)
Project Start
1996-12-18
Project End
2000-11-30
Budget Start
1997-12-01
Budget End
1998-11-30
Support Year
2
Fiscal Year
1998
Total Cost
Indirect Cost
Name
University of California San Francisco
Department
Anatomy/Cell Biology
Type
Schools of Medicine
DUNS #
073133571
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Mariani, Francesca V; Ahn, Christina P; Martin, Gail R (2008) Genetic evidence that FGFs have an instructive role in limb proximal-distal patterning. Nature 453:401-5
Lu, Pengfei; Minowada, George; Martin, Gail R (2006) Increasing Fgf4 expression in the mouse limb bud causes polysyndactyly and rescues the skeletal defects that result from loss of Fgf8 function. Development 133:33-42
Grieshammer, Uta; Cebrian, Cristina; Ilagan, Roger et al. (2005) FGF8 is required for cell survival at distinct stages of nephrogenesis and for regulation of gene expression in nascent nephrons. Development 132:3847-57
Sun, X; Lewandoski, M; Meyers, E N et al. (2000) Conditional inactivation of Fgf4 reveals complexity of signalling during limb bud development. Nat Genet 25:83-6
Lewandoski, M; Sun, X; Martin, G R (2000) Fgf8 signalling from the AER is essential for normal limb development. Nat Genet 26:460-3
Sun, X; Meyers, E N; Lewandoski, M et al. (1999) Targeted disruption of Fgf8 causes failure of cell migration in the gastrulating mouse embryo. Genes Dev 13:1834-46
Meyers, E N; Martin, G R (1999) Differences in left-right axis pathways in mouse and chick: functions of FGF8 and SHH. Science 285:403-6
Martinez, S; Crossley, P H; Cobos, I et al. (1999) FGF8 induces formation of an ectopic isthmic organizer and isthmocerebellar development via a repressive effect on Otx2 expression. Development 126:1189-200
Trumpp, A; Depew, M J; Rubenstein, J L et al. (1999) Cre-mediated gene inactivation demonstrates that FGF8 is required for cell survival and patterning of the first branchial arch. Genes Dev 13:3136-48
Neubuser, A; Peters, H; Balling, R et al. (1997) Antagonistic interactions between FGF and BMP signaling pathways: a mechanism for positioning the sites of tooth formation. Cell 90:247-55