Normal growth in children is generally accepted as a marker for health, while abnormal growth is a marker that the child may be ill or malnourished or that something may be awry in the child's environment. Children with cerebral palsy (CP) frequently grow poorly. However, normal growth patterns for children with CP have not been established, so it is often difficult to discriminate children with CP who are healthy from those who are ill. The North American Growth in Cerebral Palsy Project (NAGCePP) was developed to address the lack of data regarding growth and nutritional status in children with Cerebral Palsy.
The specific aims of this proposal are: A. To refine a clinical protocol and methodology for the comprehensive study of growth and nutritional status in children with CP B. To develop a well-equipped, multicenter network for the comprehensive study of growth and nutritional status in children with CP and to demonstrate the feasibility of this network C. To collect pilot data of growth in a representative, population- based sample of children with CP in five geographic areas in North America D. To complete collection of data of a representative, population- based sample of children with CP in order to describe expected growth patterns NAGCePP will consist of a multicenter core study coupled with one or more nested studies. The core study is to be anthropometric study of growth in a population-based, random sample of children with CP to which all centers will contribute data. Additionally, individual centers will have ongoing nested studies utilizing small subsamples to which only that individually site (or a few sites) contributes data. These nested studies will address more specific questions related to growth, nutritional status, and their effects on functional status and quality of life. This proposal requests funds for the multicenter core study and for the first nested study, which will be performed at the main study and for the first nested study, which will be performed at the main study site. This proposal aims to contribute information toward the understanding of normal growth and nutritional status in children with cerebral palsy. An understanding of normal growth in these children is a prerequisite to understanding the relationship between growth, nutritional status, functional abilities and health-related quality of life

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project (R01)
Project #
5R01HD035739-04
Application #
6183002
Study Section
Special Emphasis Panel (ZHD1-RRG-K (07))
Program Officer
Quatrano, Louis A
Project Start
1997-09-27
Project End
2002-08-31
Budget Start
2000-09-01
Budget End
2001-08-31
Support Year
4
Fiscal Year
2000
Total Cost
$109,787
Indirect Cost
Name
University of Virginia
Department
Pediatrics
Type
Schools of Medicine
DUNS #
001910777
City
Charlottesville
State
VA
Country
United States
Zip Code
22904
Gurka, Matthew J; Kuperminc, Michelle N; Busby, Marjorie G et al. (2010) Assessment and correction of skinfold thickness equations in estimating body fat in children with cerebral palsy. Dev Med Child Neurol 52:e35-41
Henderson, Richard C; Berglund, Lisa M; May, Ryan et al. (2010) The relationship between fractures and DXA measures of BMD in the distal femur of children and adolescents with cerebral palsy or muscular dystrophy. J Bone Miner Res 25:520-6
Kuperminc, Michelle N; Gurka, Matthew J; Houlihan, Christine M et al. (2009) Puberty, statural growth, and growth hormone release in children with cerebral palsy. J Pediatr Rehabil Med 2:131-141
Henderson, Richard C; Grossberg, Richard I; Matuszewski, Jeanine et al. (2007) Growth and nutritional status in residential center versus home-living children and adolescents with quadriplegic cerebral palsy. J Pediatr 151:161-6
Stevenson, Richard D; Conaway, Mark; Barrington, John W et al. (2006) Fracture rate in children with cerebral palsy. Pediatr Rehabil 9:396-403
Stevenson, Richard D; Conaway, Mark; Chumlea, W Cameron et al. (2006) Growth and health in children with moderate-to-severe cerebral palsy. Pediatrics 118:1010-8
Henderson, Richard C; Kairalla, John A; Barrington, John W et al. (2005) Longitudinal changes in bone density in children and adolescents with moderate to severe cerebral palsy. J Pediatr 146:769-75
Henderson, Richard C; Gilbert, Shawn R; Clement, Meagan E et al. (2005) Altered skeletal maturation in moderate to severe cerebral palsy. Dev Med Child Neurol 47:229-36
Lark, Robert K; Williams, Cherise L; Stadler, Diane et al. (2005) Serum prealbumin and albumin concentrations do not reflect nutritional state in children with cerebral palsy. J Pediatr 147:695-7
Henderson, Richard C; Kairalla, John; Abbas, Almas et al. (2004) Predicting low bone density in children and young adults with quadriplegic cerebral palsy. Dev Med Child Neurol 46:416-9

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