Human flavor and food preferences established early in life track into childhood and adolescence, a finding with important implications for long-term health. How such preferences develop remains a mystery, however. The primary goal of our research program is to understand how flavor and food preferences develop and are modified with experience. To this end, we investigated the very earliest flavor experiences, those which occur in utero and during breastfeeding, and demonstrated that these experiences influence the infant's acceptance of a variety of flavors and foods including vegetables. More recently, we have taken advantage of the marked flavor differences among commercial infant formulas as a model to study the effects of early experiences in infants who are formula fed. The drastic developmental changes in acceptance of formulas which are protein hydrolysate based and the finding that early exposure results in a complete shift in hedonic tone to the flavor of this formula from one of absolute distaste to eager acceptance, make it a powerful experimental tool. The effects of early exposure were particularly persistent, leading to altered preferences several years after the child's last exposure. The findings from these studies set the stage for the proposed investigation on sensitive periods in determining flavor and food preferences (""""""""flavor imprinting""""""""). To maximize the value of this research, most of the proposed studies are conducted with the same cohort of infants. These infants will be studied across their first three years of life, a period we believe is crucial to the establishment of long-term patterns of flavor and food acceptance. The results of this novel, multidisciplinary research program will have both theoretical and practical implications for understanding the sensory-guided responses of human infants and the biology of food choice. They will also provide information on strategies to overcome the difficulties in introducing hydrolysate formulas to infants who need them clinically. Children participating in each of the proposed studies will be genotyped for recently discovered taste receptor genes to determine how genetic differences contribute to the development of food preferences. New knowledge about the mechanisms underlying the formation of food preferencesand the molecular basis of food likes and dislikes in children, a generation who will struggle with obesity and diabetes, may suggest strategies to overcome diet-induced diseases.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project (R01)
Project #
5R01HD037119-10
Application #
7758308
Study Section
Special Emphasis Panel (ZRG1-BBBP-K (90))
Program Officer
Grave, Gilman D
Project Start
1999-01-01
Project End
2012-01-31
Budget Start
2010-02-01
Budget End
2012-01-31
Support Year
10
Fiscal Year
2010
Total Cost
$276,712
Indirect Cost
Name
Monell Chemical Senses Center
Department
Type
DUNS #
088812565
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Forestell, Catherine A; Mennella, Julie A (2017) The Relationship between Infant Facial Expressions and Food Acceptance. Curr Nutr Rep 6:141-147
Spector, Alan C; le Roux, Carel W; Munger, Steven D et al. (2017) Proceedings of the 2015 ASPEN Research Workshop-Taste Signaling. JPEN J Parenter Enteral Nutr 41:113-124
Mennella, Julie A; Trabulsi, Jillian C; Papas, Mia A (2016) Effects of cow milk versus extensive protein hydrolysate formulas on infant cognitive development. Amino Acids 48:697-705
Mennella, Julie A; Reiter, Ashley R; Daniels, Loran M (2016) Vegetable and Fruit Acceptance during Infancy: Impact of Ontogeny, Genetics, and Early Experiences. Adv Nutr 7:211S-219S
Mennella, Julie A; Bobowski, Nuala K; Reed, Danielle R (2016) The development of sweet taste: From biology to hedonics. Rev Endocr Metab Disord 17:171-8
Wahlqvist, Mark L; Krawetz, Stephen A; Rizzo, Nico S et al. (2015) Early-life influences on obesity: from preconception to adolescence. Ann N Y Acad Sci 1347:1-28
Ventura, A K; Inamdar, L B; Mennella, J A (2015) Consistency in infants' behavioural signalling of satiation during bottle-feeding. Pediatr Obes 10:180-7
Mennella, Julie A (2014) Ontogeny of taste preferences: basic biology and implications for health. Am J Clin Nutr 99:704S-11S
Mennella, Julie A; Finkbeiner, Susana; Lipchock, Sarah V et al. (2014) Preferences for salty and sweet tastes are elevated and related to each other during childhood. PLoS One 9:e92201
BaldeĆ³n, Manuel E; Mennella, Julie A; Flores, Nancy et al. (2014) Free amino acid content in breast milk of adolescent and adult mothers in Ecuador. Springerplus 3:104

Showing the most recent 10 out of 51 publications