The ultimate objective of this study is to understand the mechanism of vertebrate limb formation. The focus of this proposal is on limb development along its proximal-distal axis. Previous studies have established that members of the Fibroblast Growth Factor (FGF) family of secreted signaling molecules play a central role in this developmental context. However, their exact function has remained a disputed issue. Recent genetic data suggest that FGFs are important in establishing the proper size of progenitor populations prior to differentiation. In this study, genetic approaches will be employed to investigate the molecular and cellular basis of FGF function in the control of progenitor population size using mouse as a model organism. In this proposal, the validity of other previously proposed roles of FGFs in limb development would also be addressed. The data generated here will lead to a better understanding of the process of limb proximal-distal development. Since limb formation is a conserved process, our knowledge from the model organisms will provide insights into the basis for human limb defects, and the potential for regeneration of this external organ. ? ? ?

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project (R01)
Project #
5R01HD045522-03
Application #
7047757
Study Section
Development - 1 Study Section (DEV)
Program Officer
Javois, Lorette Claire
Project Start
2004-07-01
Project End
2009-04-30
Budget Start
2006-05-01
Budget End
2007-04-30
Support Year
3
Fiscal Year
2006
Total Cost
$315,122
Indirect Cost
Name
University of Wisconsin Madison
Department
Genetics
Type
Schools of Medicine
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715
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