Our overall objective is to improve the costly long-term course of mechanical low back pain (LBP). In recent work we found that people in both classification-specific and non-specific treatment groups displayed clinically meaningful improvements in pain and function, but differences between groups were smaller than expected. A possible reason for the attenuated group differences can be found in 3 related facts: 1) in addition to specific or non-specific exercise, both groups received training aimed at modifying the pattern of movement and alignment used in the lumbar spine during functional activities, 2) adherence levels were higher and more prolonged for training in functional activities than for exercise, and 3) outcomes continued to improve for about 6 months after the treatment phase but then gradually reversed along with declines in adherence to training in functional activities. In the current project we will capitalize on the effect of training people to modify their movement and alignment patterns during daily functional activities. This will be done by using a motor skill training program which emphasizes challenging practice in performance of functional activities painlessly with appropriate patterns of movement and alignment. We will also attempt to prolong the beneficial effects of the motor skill training by including a booster treatment 6 months after the initial treatment. To accomplish this we will conduct a prospective, randomized, controlled clinical trial in which people with chronic LBP will be randomized to a treatment of either motor skill training or commonly prescribed, evidence-based, strength and flexibility exercises. Treatment will be provided in 2 phases: 1) initial phase: 6 - 1 hour sessions, once/week for 6 weeks, and 2) booster phase: 1-3 sessions beginning 6 months after the initial phase. We will collect 1) pain, functional limitation, disability, and economic outcomes, 2) reports of adherence, and 3) instrumented measurements of movement and alignment patterns during functional activities. People will be followed for 12 months after the initial treatment phase. We will test 1 if motor skill training results in better outcomes and better adherence than strength and flexibility exercise in the 12 months after treatment, and 2) the effect of a booster treatment provided 6 months after the treatment phase on functional limitations and adherence to treatment. Finally we will examine the relationship between functional limitations and 1) treatment adherence, and 2) movement and alignment patterns displayed during functional activities. Expected outcomes from this project are specific recommendations for the use and timing of motor skill training during functional activities for people with LBP. Successful completion of this project will have an immediate, high impact on rehabilitation research and treatment of people with LBP. In addition, the approach described could be used to study other similarly long-term, costly, and function-limiting musculoskeletal pain conditions.

Public Health Relevance

Mechanical low back pain is a highly prevalent and costly medical condition characterized by fluctuating pain and limitations in function. In this grant we will work to understand the role of motor skill training to modify movements and alignments during functional activities and the use of booster treatments on the long-term course of low back pain.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project (R01)
Project #
4R01HD047709-08
Application #
9038401
Study Section
Musculoskeletal Rehabilitation Sciences Study Section (MRS)
Program Officer
Marden, Susan F
Project Start
2006-06-10
Project End
2018-03-31
Budget Start
2016-04-01
Budget End
2017-03-31
Support Year
8
Fiscal Year
2016
Total Cost
Indirect Cost
Name
Washington University
Department
Other Health Professions
Type
Schools of Medicine
DUNS #
068552207
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Harris-Hayes, Marcie; Steger-May, Karen; van Dillen, Linda R et al. (2018) Reduced Hip Adduction Is Associated With Improved Function After Movement-Pattern Training in Young People With Chronic Hip Joint Pain. J Orthop Sports Phys Ther 48:316-324
Chimenti, Ruth L; Van Dillen, Linda R; Khoo-Summers, Lynnette (2017) Use of a Patient-Specific Outcome Measure and a Movement Classification System to Guide Nonsurgical Management of a Circus Performer with Low Back Pain: A Case Report. J Dance Med Sci 21:185-192
Sahrmann, Shirley; Azevedo, Daniel C; Dillen, Linda Van (2017) Diagnosis and treatment of movement system impairment syndromes. Braz J Phys Ther 21:391-399
Shojaei, Iman; Vazirian, Milad; Salt, Elizabeth G et al. (2017) Timing and magnitude of lumbar spine contribution to trunk forward bending and backward return in patients with acute low back pain. J Biomech 53:71-77
Marich, Andrej V; Hwang, Ching-Ting; Salsich, Gretchen B et al. (2017) Consistency of a lumbar movement pattern across functional activities in people with low back pain. Clin Biomech (Bristol, Avon) 44:45-51
Shojaei, Iman; Salt, Elizabeth G; Hooker, Quenten et al. (2017) Comparison of lumbo-pelvic kinematics during trunk forward bending and backward return between patients with acute low back pain and asymptomatic controls. Clin Biomech (Bristol, Avon) 41:66-71
Vazirian, Milad; Van Dillen, Linda; Bazrgari, Babak (2016) Lumbopelvic rhythm during trunk motion in the sagittal plane: A review of the kinematic measurement methods and characterization approaches. Phys Ther Rehabil 3:
Vazirian, Milad; Van Dillen, Linda R; Bazrgari, Babak (2016) Lumbopelvic rhythm in the sagittal plane: A review of the effects of participants and task characteristics. Int Musculoskelet Med 38:51-58
Sorensen, Christopher J; George, Steven Z; Callaghan, Jack P et al. (2016) Psychological Factors Are Related to Pain Intensity in Back-Healthy People Who Develop Clinically Relevant Pain During Prolonged Standing: A Preliminary Study. PM R 8:1031-1038
Van Dillen, Linda R; Norton, Barbara J; Sahrmann, Shirley A et al. (2016) Efficacy of classification-specific treatment and adherence on outcomes in people with chronic low back pain. A one-year follow-up, prospective, randomized, controlled clinical trial. Man Ther 24:52-64

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