Physical rehabilitation is the main treatment for motor disorders. Yet we are far from understanding the essential principles of rehabilitation training in adults, and know even less about children. Our long-term goals are to identify critical features of the motor learning process, understand how they change during development, and discover how to optimize them for rehabilitating children and adults with hemiparesis. Here we focus on optimizing motor learning during split-belt treadmill training, a technique that shows strong promise for producing dramatic improvements in walking patterns. We have shown that deficit exaggeration during split-belt training can correct walking deficits in children and adults with hemiparesis. Specifically, exaggerating the problem by making one leg walk faster than the other drives the nervous system to adapt, and this improves walking patterns when the person returns to normal conditions. We believe that split-belt deficit exaggeration could become an important clinical approach. However, there are two critical motor learning features requiring further study to guide clinical application. First, we need to optimize generalization from split-belt walking to walking under natural conditions. Split-belt adaptation generalizes only partially to natural over-ground walking. This is a common problem with any device or robot based training strategy, where training conditions do not match real-world contexts. Thus, we will study how manipulating the sensory context with virtual reality and changing attention to the movement influence generalization. Second, we need to optimize retention of adapted walking patterns, in order to produce long-term improvements in natural walking. In previous experiments, adaptation faded within 10 20 minutes. In the proposed experiments, we will study how attention and training schedule can be used to extend retention. In all three aims, we will assess effects of age (3-adult) and presence of hemiparesis from cerebral damage. Overall, we believe our results will show how deficit exaggeration during split-belt treadmill training could be used to produce long-term improvements in natural walking.

Public Health Relevance

Walking disturbances are some of the most common problems for people with brain damage. In this grant, we will work to understand how split-belt treadmill training can help people learn to improve their walking patterns.

National Institute of Health (NIH)
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Research Project (R01)
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Musculoskeletal Rehabilitation Sciences Study Section (MRS)
Program Officer
Michel, Mary E
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Hugo W. Moser Research Institute Kennedy Krieger
United States
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Patrick, Susan K; Musselman, Kristin E; Tajino, Junichi et al. (2014) Prior experience but not size of error improves motor learning on the split-belt treadmill in young children. PLoS One 9:e93349
Finley, James M; Statton, Matthew A; Bastian, Amy J (2014) A novel optic flow pattern speeds split-belt locomotor adaptation. J Neurophysiol 111:969-76
Malone, Laura A; Bastian, Amy J (2014) Spatial and temporal asymmetries in gait predict split-belt adaptation behavior in stroke. Neurorehabil Neural Repair 28:230-40
Finley, James M; Bastian, Amy J; Gottschall, Jinger S (2013) Learning to be economical: the energy cost of walking tracks motor adaptation. J Physiol 591:1081-95
Hoyer, Erik H; Bastian, Amy J (2013) The effects of task demands on bimanual skill acquisition. Exp Brain Res 226:193-208
Reisman, Darcy S; McLean, Heather; Keller, Jennifer et al. (2013) Repeated split-belt treadmill training improves poststroke step length asymmetry. Neurorehabil Neural Repair 27:460-8
Torres-Oviedo, Gelsy; Bastian, Amy J (2012) Natural error patterns enable transfer of motor learning to novel contexts. J Neurophysiol 107:346-56
Torres-Oviedo, Gelsy; Vasudevan, Erin; Malone, Laura et al. (2011) Locomotor adaptation. Prog Brain Res 191:65-74
Malone, Laura A; Vasudevan, Erin V L; Bastian, Amy J (2011) Motor adaptation training for faster relearning. J Neurosci 31:15136-43
Vasudevan, Erin V L; Torres-Oviedo, Gelsy; Morton, Susanne M et al. (2011) Younger is not always better: development of locomotor adaptation from childhood to adulthood. J Neurosci 31:3055-65

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