Physical rehabilitation is the main treatment for motor disorders. Yet we are far from understanding the essential principles of rehabilitation training in adults, and know even less about children. Our long-term goals are to identify critical features of the motor learning process, understand how they change during development, and discover how to optimize them for rehabilitating children and adults with hemiparesis. Here we focus on optimizing motor learning during split-belt treadmill training, a technique that shows strong promise for producing dramatic improvements in walking patterns. We have shown that deficit exaggeration during split-belt training can correct walking deficits in children and adults with hemiparesis. Specifically, exaggerating the problem by making one leg walk faster than the other drives the nervous system to adapt, and this improves walking patterns when the person returns to normal conditions. We believe that split-belt deficit exaggeration could become an important clinical approach. However, there are two critical motor learning features requiring further study to guide clinical application. First, we need to optimize generalization from split-belt walking to walking under natural conditions. Split-belt adaptation generalizes only partially to natural over-ground walking. This is a common problem with any device or robot based training strategy, where training conditions do not match real-world contexts. Thus, we will study how manipulating the sensory context with virtual reality and changing attention to the movement influence generalization. Second, we need to optimize retention of adapted walking patterns, in order to produce long-term improvements in natural walking. In previous experiments, adaptation faded within 10 20 minutes. In the proposed experiments, we will study how attention and training schedule can be used to extend retention. In all three aims, we will assess effects of age (3-adult) and presence of hemiparesis from cerebral damage. Overall, we believe our results will show how deficit exaggeration during split-belt treadmill training could be used to produce long-term improvements in natural walking.

Public Health Relevance

Walking disturbances are some of the most common problems for people with brain damage. In this grant, we will work to understand how split-belt treadmill training can help people learn to improve their walking patterns.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project (R01)
Project #
5R01HD048741-08
Application #
8464178
Study Section
Musculoskeletal Rehabilitation Sciences Study Section (MRS)
Program Officer
Michel, Mary E
Project Start
2006-07-01
Project End
2015-05-31
Budget Start
2013-06-01
Budget End
2014-05-31
Support Year
8
Fiscal Year
2013
Total Cost
$301,439
Indirect Cost
$105,427
Name
Hugo W. Moser Research Institute Kennedy Krieger
Department
Type
DUNS #
155342439
City
Baltimore
State
MD
Country
United States
Zip Code
21205
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Finley, James M; Bastian, Amy J (2016) Associations Between Foot Placement Asymmetries and Metabolic Cost of Transport in Hemiparetic Gait. Neurorehabil Neural Repair :
Musselman, Kristin E; Roemmich, Ryan T; Garrett, Ben et al. (2016) Motor learning in childhood reveals distinct mechanisms for memory retention and re-learning. Learn Mem 23:229-37
Malone, Laura A; Bastian, Amy J (2016) Age-related forgetting in locomotor adaptation. Neurobiol Learn Mem 128:1-6
Day, Kevin A; Roemmich, Ryan T; Taylor, Jordan A et al. (2016) Visuomotor Learning Generalizes Around the Intended Movement. eNeuro 3:
Ankaralı, M Mert; Sefati, Shahin; Madhav, Manu S et al. (2015) Walking dynamics are symmetric (enough). J R Soc Interface 12:0150209
Long, Andrew W; Finley, James M; Bastian, Amy J (2015) A marching-walking hybrid induces step length adaptation and transfers to natural walking. J Neurophysiol 113:3905-14
Finley, James M; Long, Andrew; Bastian, Amy J et al. (2015) Spatial and Temporal Control Contribute to Step Length Asymmetry During Split-Belt Adaptation and Hemiparetic Gait. Neurorehabil Neural Repair 29:786-95
Roemmich, Ryan T; Bastian, Amy J (2015) Two ways to save a newly learned motor pattern. J Neurophysiol 113:3519-30
Patrick, Susan K; Musselman, Kristin E; Tajino, Junichi et al. (2014) Prior experience but not size of error improves motor learning on the split-belt treadmill in young children. PLoS One 9:e93349

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