The current Standard of Care for the rehabilitation of severely burned children is to discharge the patient from the hospital, with a written set of instructions for physical and occupational therapy activities at home, in an unsupervised environment. These activities do not significantly impact the persistent and extensive skeletal muscle catabolism and weakness characteristic of severe burns. The central hypothesis of this grant is that a supervised anld structured aerobic and resistance exercise program implemented at hospital discharge in severely burned children will improve physical structure and function, allowing for an improvement in quality of life (QOL). We propose the following specific aims (SA): SA1 will test the hypothesis that in severely burned children, a supervised and structured exercise program will significantly increase muscle mass and bone mass more than the current Standard of Care. SA2 will test the hypothesis that in burned children,

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project (R01)
Project #
5R01HD049471-06
Application #
8098793
Study Section
Skeletal Muscle and Exercise Physiology Study Section (SMEP)
Program Officer
Nicholson, Carol E
Project Start
2006-08-01
Project End
2015-01-31
Budget Start
2011-02-01
Budget End
2012-01-31
Support Year
6
Fiscal Year
2011
Total Cost
$260,534
Indirect Cost
Name
University of Texas Medical Br Galveston
Department
Surgery
Type
Schools of Medicine
DUNS #
800771149
City
Galveston
State
TX
Country
United States
Zip Code
77555
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Wurzer, Paul; Guillory, Ashley; Parvizi, Daryousch et al. (2017) Human herpes viruses in burn patients: A systematic review. Burns 43:25-33
Cambiaso-Daniel, Janos; Voigt, Charles D; Rivas, Eric et al. (2017) Correlation Between PaO2/FIO2 and Peripheral Capillary Oxygenation/FIO2 in Burned Children With Smoke Inhalation Injury. Pediatr Crit Care Med 18:e472-e476
Chao, Tony; Porter, Craig; Herndon, David N et al. (2017) Propranolol and Oxandrolone Therapy Accelerated Muscle Recovery in Burned Children. Med Sci Sports Exerc :
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Lee, Jong O; Herndon, David N; Andersen, Clark et al. (2017) Effect of Exercise Training on the Frequency of Contracture-Release Surgeries in Burned Children. Ann Plast Surg 79:346-349

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