The health effects on children who witness and/or directly experience domestic violence has been identified as a leading public health issue, although its impact on children's health has not been well delineated. Growing research demonstrates the short- and long-term adverse physical, psychological, and behavioral consequences among children growing up with chronic violence. Chronic traumatic stress related to intimate violence (including remote exposures during early childhood) is associated with lasting biological changes known to cause alterations in immune functions potentially important to the pathophysiology of many diseases including obesity. Chronic stress can lead to neuroendocrine dysregulation (HPA and HPG axes) and can in turn have profound inhibitory effects on growth and sex steroid hormones. Therefore, exposure to violence may be associated with the development of obesity/overweight by causing changes in growth and sex steroid hormones. Also, stress-induced neuroendocrine disruption may be associated with reproductive health outcomes including early menarche, menstrual irregularity, and chronic functional pelvic/abdominal pain. Furthermore, these shared pathways may in part explain the link between obesity and these reproductive outcomes. No prospective study has examined the relationship between early life family violence exposure and the trajectory of weight gain in childhood and adolescence or the incidence of childhood obesity. Moreover, no studies exist to date which explore the influence of obesity, as a mediator of the relationship between violence as a chronic stressor and reproductive health outcomes in adolescents and young adults. We propose to measure family violence exposure in a sub-cohort of adolescents and young adults participating in the Growing Up Today Study (GUTS) (n approximately 16000) which provides a working infrastructure to facilitate this undertaking. In addition, salivary cortisol rhythms will be examined in relation to history of violence exposure and as a mediator between violence exposure and the proposed outcomes in a subsample (n=1200).

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project (R01)
Project #
5R01HD049889-05
Application #
7840482
Study Section
Special Emphasis Panel (ZRG1-BBBP-J (50))
Program Officer
Haverkos, Lynne
Project Start
2006-08-01
Project End
2012-05-31
Budget Start
2010-06-01
Budget End
2012-05-31
Support Year
5
Fiscal Year
2010
Total Cost
$320,346
Indirect Cost
Name
Brigham and Women's Hospital
Department
Type
DUNS #
030811269
City
Boston
State
MA
Country
United States
Zip Code
02115
Rosa, Maria José; Just, Allan C; Tamayo Y Ortiz, Marcela et al. (2016) Prenatal and postnatal stress and wheeze in Mexican children: Sex-specific differences. Ann Allergy Asthma Immunol 116:306-312.e1
Sonneville, Kendrin R; Grilo, Carlos M; Richmond, Tracy K et al. (2015) Prospective association between overvaluation of weight and binge eating among overweight adolescent girls. J Adolesc Health 56:25-9
Field, Alison E; Sonneville, Kendrin R; Crosby, Ross D et al. (2014) Prospective associations of concerns about physique and the development of obesity, binge drinking, and drug use among adolescent boys and young adult men. JAMA Pediatr 168:34-9
Swanson, Sonja A; Horton, Nicholas J; Crosby, Ross D et al. (2014) A latent class analysis to empirically describe eating disorders through developmental stages. Int J Eat Disord 47:762-72
Cerdá, M; Bordelois, P; Keyes, K M et al. (2014) Family ties: maternal-offspring attachment and young adult nonmedical prescription opioid use. Drug Alcohol Depend 142:231-8
Roberts, Andrea L; Rosario, Margaret; Slopen, Natalie et al. (2013) Childhood gender nonconformity, bullying victimization, and depressive symptoms across adolescence and early adulthood: an 11-year longitudinal study. J Am Acad Child Adolesc Psychiatry 52:143-52
Roberts, Andrea L; Rosario, Margaret; Corliss, Heather L et al. (2013) Sexual orientation and functional pain in U.S. young adults: the mediating role of childhood abuse. PLoS One 8:e54702
Iron-Segev, Sharon; Peterson, Karen E; Gillman, Matthew W et al. (2013) Associations of breastfeeding with bulimic behaviors and eating disorders among adolescents. Int J Eat Disord 46:834-40
Jun, Hee-Jin; Corliss, Heather L; Boynton-Jarrett, Renée et al. (2012) Growing up in a domestic violence environment: relationship with developmental trajectories of body mass index during adolescence into young adulthood. J Epidemiol Community Health 66:629-35
Sonneville, K R; Calzo, J P; Horton, N J et al. (2012) Body satisfaction, weight gain and binge eating among overweight adolescent girls. Int J Obes (Lond) 36:944-9

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