This project will capitalize on, extend, and enhance the Chicago Community Adult Health Study(CCAHS), (P50 HD 38986) which is designed to become a major prospective multi-level study of the impact of individual and social environmental factors on health, their role in understanding socioeconomic and racial- ethnic disparities in health, and the biological and behavioral pathways that are involved. This project has completed a major survey of a probability sample of 3105 adults age 18+ in the city of Chicago, with a response rate of 72% and including physical measurements of height, weight, waist, hip length, and blood pressure. In addition, saliva and/or a blood sample have been collected for 661 people (60% of respondents in a subsample of 80 of the 343 neighborhood clusters (NCs) covering the entire city of Chicago, developed and characterized by the Project on Human Development in Chicago Neighborhoods (PHDCN) (, from which the CCAHS sample is drawn. In addition to utilizing existing and collecting new archival data on these areas, the CCAHS carried out Systematic Social Observations of 1664 blocks containing sampled households for the study. Thus, the current proposal seeks to utilize all these data to extend and enhance the CCAHS as follows: 1) to estimate via state of the art multi-level analysis the role in health and health disparities of the immediate social contexts or """"""""neighborhoods"""""""" in which people live; 2) to estimate how a wide range of aspects of immediate residential contexts and broader social contexts (assessed by multiple methods and measures and considered both singly and in interaction with each other and individual and household factors) affect health and health disparities and help to understand or flesh out the role of social context in health; 3) to estimate via innovative new methods the role in health and health disparities of the broader social contexts which surround more immediate residential contexts; and 4) to begin to convert the existing cross-sectional study into a longitudinal and prospective study via respondent tracking and mortality follow-up, which will allow initial prospective analyses of the predictive association with mortality of individual, household, and contextual psychosocial risk factors for health assessed in the CCAHS, as well as laying the foundation for a second wave of data collection in 2008-9, which will be funded by a subsequent competing renewal proposal, and allow for prospective analyses with respect to the full range of health outcomes in CCAHS. This study will importantly advance the understanding of socioeconomic and racial/ethnic disparities in health - a major priority of the Public Health Service and National Institutes of Health for the new millenium.

National Institute of Health (NIH)
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Research Project (R01)
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Study Section
Social Sciences and Population Studies Study Section (SSPS)
Program Officer
Spittel, Michael
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University of Michigan Ann Arbor
Biostatistics & Other Math Sci
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Ann Arbor
United States
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Gilster, Megan E (2016) Racial and Ethnic Differences in the Neighborhood Context of Mastery. J Community Psychol 44:38-50
Hicken, Margaret T; Lee, Hedwig; Morenoff, Jeffrey et al. (2014) Racial/ethnic disparities in hypertension prevalence: reconsidering the role of chronic stress. Am J Public Health 104:117-23
Slopen, Natalie; Williams, David R (2014) Discrimination, other psychosocial stressors, and self-reported sleep duration and difficulties. Sleep 37:147-56
Gilster, Megan E (2014) Putting Activism in Its Place: The Neighborhood Context of Participation in Neighborhood-Focused Activism. J Urban Aff 36:33-50
Gilster, Megan E (2014) Neighborhood stressors, mastery, and depressive symptoms: racial and ethnic differences in an ecological model of the stress process in Chicago. J Urban Health 91:690-706
Slopen, Natalie; Non, Amy; Williams, David R et al. (2014) Childhood adversity, adult neighborhood context, and cumulative biological risk for chronic diseases in adulthood. Psychosom Med 76:481-9
Hunte, Haslyn E R; King, Katherine; Hicken, Margaret et al. (2013) Interpersonal discrimination and depressive symptomatology: examination of several personality-related characteristics as potential confounders in a racial/ethnic heterogeneous adult sample. BMC Public Health 13:1084
Keene, Danya; Bader, Michael; Ailshire, Jennifer (2013) Length of residence and social integration: the contingent effects of neighborhood poverty. Health Place 21:171-8
Hunte, Haslyn E R; Finlayson, Tracy L (2013) The relationship between perceived discrimination and psychotherapeutic and illicit drug misuse in Chicago, IL, USA. J Urban Health 90:1112-29
Viruell-Fuentes, Edna A; Morenoff, Jeffrey D; Williams, David R et al. (2013) Contextualizing nativity status, Latino social ties, and ethnic enclaves: an examination of the 'immigrant social ties hypothesis'. Ethn Health 18:586-609

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