In this application we propose to develop a sophisticated, kinematic-driven computational model of the human wrist. Our model will be revolutionary in that it will be fully three-dimensional (3-D), and will include fifteen cartilage-wrapped bones, as well as most carpal ligaments. Current models of the wrist are limited in their sophistication and/or scope. Our model will be driven by subject-specific kinematic data validated against the largest collection of in vivo wrist kinematic data in existence. Development of this model is the logical extension of our previous work which involved the creation and implementation of novel imaging and computational methodologies for the noninvasive measurement of 3-D carpal bone kinematics in vivo. It will involve the refinement of new methodologies to generate high-resolution digital models of the intricate carpal anatomy. The creation and validation of new tools for generating morphological maps of cartilage and ligaments from micro-computed tomograpic images, a novel algorithm for computing cartilage surface deformations, and a novel algorithm for modeling ligament fiber paths constrained to wrap around bony prominences will also be developed. The model will be immediately useful for analyzing the biomechanics of the normal and pathological wrist. In particular, it will provide heretofore unavailable insight into the role of individual wrist ligaments, as well as the implications of altered kinematics on cartilage contact. The model will also be an important intermediate step in our ultimate goal to develop a load-driven, predictive computational model of the wrist. All the bony, cartilage and ligamentous digital anatomy, kinematic data, and mechanical properties generated in the development of this kinematic-driven model will be directly applicable to a load-driven model. A sophisticated computational model of the wrist has the potential to completely transform the field of wrist research, allowing researchers to explore basic questions that could not be answered with traditional experimental methods, and clinicians to evaluate surgical techniques. The model will hasten discovery of how the wrist functions and how wrist function is altered by injury and surgical intervention. These discoveries will lead to new treatments for wrist disease and trauma, which affect men and women of all ages, and account for significant medical expenses and lost productivity each year.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project (R01)
Project #
5R01HD052127-04
Application #
7619291
Study Section
Musculoskeletal Tissue Engineering Study Section (MTE)
Program Officer
Shinowara, Nancy
Project Start
2006-07-01
Project End
2011-04-30
Budget Start
2009-05-01
Budget End
2011-04-30
Support Year
4
Fiscal Year
2009
Total Cost
$314,433
Indirect Cost
Name
Rhode Island Hospital
Department
Type
DUNS #
075710996
City
Providence
State
RI
Country
United States
Zip Code
02903
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Rainbow, Michael J; Kamal, Robin N; Leventhal, Evan et al. (2013) In vivo kinematics of the scaphoid, lunate, capitate, and third metacarpal in extreme wrist flexion and extension. J Hand Surg Am 38:278-88
Rainbow, Michael J; Crisco, Joseph J; Moore, Douglas C et al. (2012) Elongation of the dorsal carpal ligaments: a computational study of in vivo carpal kinematics. J Hand Surg Am 37:1393-9
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Moore, Douglas C; Casey, Jane A; Gilbert, Susannah L et al. (2011) ?CT-generated carpal cartilage surfaces: validation of a technique. J Biomech 44:2516-9
Crisco, Joseph J; Heard, Wendell M R; Rich, Ryan R et al. (2011) The mechanical axes of the wrist are oriented obliquely to the anatomical axes. J Bone Joint Surg Am 93:169-77
Marai, G; Crisco, Joseph J; Laidlaw, David H (2009) Development of a kinematic 3D carpal model to analyze in vivo soft-tissue interaction across multiple static postures. Conf Proc IEEE Eng Med Biol Soc 2009:7176-9
Rainbow, Michael J; Crisco, Joseph J; Moore, Douglas C et al. (2008) Gender differences in capitate kinematics are eliminated after accounting for variation in carpal size. J Biomech Eng 130:041003