Stroke patients with motor impairment and difficulties performing activities of daily living (ADL) require interventions to enhance the beneficial effects of physical training on motor rehabilitation. A crucial first step in the acquisition of complex motor skills, such as those used to perform ADL, is motor training, which results in the formation of motor memories. The ability to form motor memories is reduced in older adults, particularly if they are affected by stroke. Therefore, new strategies are required to compensate for this deficit. Action observation (AO), observing another individual perform motor training, is one such strategy since it enhances the effects of motor training in healthy older adults. However, the effects of action observation on motor memory formation and ADL are unknown in stroke patients. Here, we propose to test the hypothesis that AO will enhance the effects of motor training on motor memory formation and ADL in chronic stroke patients compared to motor training alone. To accomplish this we will conduct a cross over study with 3 interventions: motor training (MT), motor training combined with AO of movements performed in the training direction (MT+AO), and motor training combined with observation of training in the opposite direction to the physically practiced (MT-AO). To determine the effects of these interventions we will measure: a) the magnitude of motor memory formation using MRI-guided transcranial magnetic stimulation (TMS);b) cortical activation changes using functional MRI (fMRI);and c) changes in ADL performance after training with each intervention. This investigation will clarify the underlying mechanisms and potential use of a new scientifically sound strategy to enhance motor function after stroke. There is no universally accepted treatment to enhance training effects after stroke. In this setting, action observation could evolve into an economical and easily implemented strategy to help address a significant public health burden.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project (R01)
Project #
5R01HD053793-07
Application #
8471133
Study Section
Special Emphasis Panel (ZRG1-MOSS-L (50))
Program Officer
Michel, Mary E
Project Start
2007-07-27
Project End
2015-01-31
Budget Start
2013-05-01
Budget End
2014-04-30
Support Year
7
Fiscal Year
2013
Total Cost
$353,892
Indirect Cost
$138,104
Name
Johns Hopkins University
Department
None
Type
Schools of Medicine
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Schlerf, John E; Galea, Joseph M; Spampinato, Danny et al. (2015) Laterality Differences in Cerebellar-Motor Cortex Connectivity. Cereb Cortex 25:1827-34
Celnik, Pablo (2015) Understanding and modulating motor learning with cerebellar stimulation. Cerebellum 14:171-4
Celnik, Pablo; Birmbaumer, Niels (2014) "How much will I recover, doctor?" Some help with an ever-elusive answer. Neurology 82:192-3
Salas, Rachel E; Galea, Joseph M; Gamaldo, Alyssa A et al. (2014) Increased use-dependent plasticity in chronic insomnia. Sleep 37:535-44
Cantarero, Gabriela; Tang, Byron; O'Malley, Rebecca et al. (2013) Motor learning interference is proportional to occlusion of LTP-like plasticity. J Neurosci 33:4634-41
Cantarero, Gabriela; Lloyd, Ashley; Celnik, Pablo (2013) Reversal of long-term potentiation-like plasticity processes after motor learning disrupts skill retention. J Neurosci 33:12862-9
Block, Hannah; Bastian, Amy; Celnik, Pablo (2013) Virtual lesion of angular gyrus disrupts the relationship between visuoproprioceptive weighting and realignment. J Cogn Neurosci 25:636-48
Block, Hannah; Celnik, Pablo (2013) Stimulating the cerebellum affects visuomotor adaptation but not intermanual transfer of learning. Cerebellum 12:781-93
Jayaram, Gowri; Tang, Byron; Pallegadda, Rani et al. (2012) Modulating locomotor adaptation with cerebellar stimulation. J Neurophysiol 107:2950-7
Galea, Joseph M; Vazquez, Alejandro; Pasricha, Neel et al. (2011) Dissociating the roles of the cerebellum and motor cortex during adaptive learning: the motor cortex retains what the cerebellum learns. Cereb Cortex 21:1761-70

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