The objective of this randomized clinical trial is to address the relative effectiveness of three distinct treatment strategies for children with comorbid ADHD and reading difficulties (RD). Despite the commonly observed overlap of ADHD and RD, little research has been conducted to determine whether established disorder-specific interventions, alone or in combination, are effective for addressing the needs of children with these co-occurring difficulties. A sample of 288 elementary school children with ADHD and RD will be recruited across two sites and randomly assigned to three groups: (a) disorder-specific ADHD treatment (careful medication management + behavioral parent training), (b) disorder-specific RD treatment (highly intensive reading instruction), or (c) the combination of ADHD and RD treatments. Pre- and post- intervention measures will be used to evaluate a variety of behavioral and academic outcomes including ADHD symptomatology and word reading abilities. We address 3 specific aims:
Aim 1 (Disorder-Specific Treatment) involves the examination of the relative benefits of providing either disorder-specific ADHD or RD treatment to children with comorbid ADHD/RD.
Aim 2 (Combined Treatment) addresses whether intensive reading intervention + careful medication management and behavioral intervention is more effective than either of these interventions alone for improving word reading and decreasing ADHD symptomatology in children with ADHD and RD.
Aim 3 (Moderators) involves the examination of variables that may moderate disorder- specific treatment response in children with comorbid ADHD and RD. We expect that outcomes may be moderated by variables such as demographic variables (e.g., SES) and severity of ADHD and reading impairment.

Public Health Relevance

The objective of this randomized clinical trial is to address unanswered questions about the relative effectiveness of treatments for children with both ADHD and significant reading difficulties (RD), a commonly observed comorbidity. We propose 3 specific aims related to attentional and word reading outcomes for students with comorbid ADHD and RD when provided with either (a) disorder-specific ADHD treatment (medication + parent training), (b) disorder-specific RD treatment (intensive direct reading instruction), or (c) the combination of ADHD and RD treatment. The first two aims address the relative benefits of providing either disorder-specific ADHD or RD treatment alone (Aim 1) and providing the combined treatment (Aim 2), while the third aim examines the effects of moderator variables on the disorder-specific treatment outcomes.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project (R01)
Project #
5R01HD060617-03
Application #
8227940
Study Section
Special Emphasis Panel (ZRG1-BBBP-C (02))
Program Officer
Miller, Brett
Project Start
2010-04-01
Project End
2015-02-28
Budget Start
2012-03-01
Budget End
2013-02-28
Support Year
3
Fiscal Year
2012
Total Cost
$974,992
Indirect Cost
$155,098
Name
University of Texas Health Science Center Houston
Department
Pediatrics
Type
Schools of Medicine
DUNS #
800771594
City
Houston
State
TX
Country
United States
Zip Code
77225
Mano, Quintino R; Jastrowski Mano, Kristen E; Guerin, Julia M et al. (2018) Fluid reasoning and reading difficulties among children with ADHD. Appl Neuropsychol Child :1-12
Tamm, Leanne; Denton, Carolyn A; Epstein, Jeffery N et al. (2017) Comparing treatments for children with ADHD and word reading difficulties: A randomized clinical trial. J Consult Clin Psychol 85:434-446
Mano, Quintino R; Jastrowski Mano, Kristen E; Denton, Carolyn A et al. (2017) Gender Moderates Association Between Emotional-Behavioral Problems and Text Comprehension in Children with Both Reading Difficulties and Adhd. Psychol Sch 54:504-518
Roberts, Greg; Rane, Shruti; Fall, Anna-Mária et al. (2015) The Impact of Intensive Reading Intervention on Level of Attention in Middle School Students. J Clin Child Adolesc Psychol 44:942-53
Tamm, Leanne; Epstein, Jeffery N; Denton, Carolyn A et al. (2014) Reaction time variability associated with reading skills in poor readers with ADHD. J Int Neuropsychol Soc 20:292-301