Understanding the factors underlying the heterogeneity of social and communicative abilities in children with autism spectrum disorders (ASD) is a critical step toward designing individualized interventions and predicting developmental trajectories. As attention contributes to typical variation in social and communicative development, and attention is often atypical in individuals with ASD, it is possible that attention contributes to the variance in social and communication skills found in young children with ASD, and may predict social- communication growth in early childhood. Indeed, NIH has called for longitudinal investigations of the role of attention in shaping social and communication development in autism. However, whilst joint attention is known to be critical in socio-communicative development in ASD, little is known about the role of other domains of attention in shaping these trajectories. This proposal examines whether performance in a range of attention domains contribute to variability in social and communication skill in young children with ASD, children with neurotypical development (NT), and younger siblings of children with ASD. The study examines the relations between attention and social and communication skill between 9- and 48- months of age. This project involves three studies: (1) Attention and Cardiovascular Reactivity in Children aged 2 to 4 years with ASD and NT. This project will examine the relation between attention and regulation in social- communication skills in early childhood and prediction of social-communication growth through six-month and one-year follow-up assessments. (2) Social-communication and Language Outcomes in Younger Siblings of Children with ASD. In younger siblings of children with autism, the project will examine the relations between attention and regulation in infancy and social-communication and language skills in early childhood. Infant siblings who were initially tested at 6-, 12- and 18-months will be followed up at 36 months. This project will focus on early attention skills and their relation to later attention, regulation, social-communication, and language ability. (3) Attention and Cardiovascular Reactivity from Infancy to Childhood. Future assessments of high-risk populations requires that assessments of critical domains be designed to assess individuals during pre-symptomatic phases, during the emergence of symptoms as well as when stable diagnoses can be formed. This project will examine the stability and reliability of the measures used to characterize the phases of attention, and their contribution to feature attention, spatial attention and joint attention, in both social and non- social domains in a sample of neurotypical infants between 9 and 48 months of age and children with ASD between 24 and 48 months of age. In summary, we propose that measures of attention and cardiovascular reactivity may be predictors of social-communication growth trajectories and indicators of targets for individualized intervention.

Public Health Relevance

Current estimates suggest that one in 150 children have a diagnosis of an Autism Spectrum Disorder (ASD), but there is also striking heterogeneity in social and communication abilities across the spectrum. Understanding the factors that contribute to the emergence and growth of social and communication skills in the early development of children with ASD is critical to understanding this heterogeneity, and in the design and targeting of individualized intervention. This project examines the contribution of attention and regulation to individual differences in social and communication skill in the first five years of life, with the goal of identifying predictors of developmental course and potential targets for intervention.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project (R01)
Project #
5R01HD064820-02
Application #
8133001
Study Section
Child Psychopathology and Developmental Disabilities Study Section (CPDD)
Program Officer
Kau, Alice S
Project Start
2010-08-20
Project End
2015-06-30
Budget Start
2011-07-01
Budget End
2012-06-30
Support Year
2
Fiscal Year
2011
Total Cost
$352,532
Indirect Cost
Name
Seattle Children's Hospital
Department
Type
DUNS #
048682157
City
Seattle
State
WA
Country
United States
Zip Code
98105
Jones, E J H; Dawson, G; Webb, S J (2017) Sensory hypersensitivity predicts enhanced attention capture by faces in the early development of ASD. Dev Cogn Neurosci :
Webb, Sara Jane; Neuhaus, Emily; Faja, Susan (2017) Face perception and learning in autism spectrum disorders. Q J Exp Psychol (Hove) 70:970-986
Charman, Tony; Young, Gregory S; Brian, Jessica et al. (2017) Non-ASD outcomes at 36 months in siblings at familial risk for autism spectrum disorder (ASD): A baby siblings research consortium (BSRC) study. Autism Res 10:169-178
Navot, N; Jorgenson, A G; Webb, S J (2017) Maternal experience raising girls with autism spectrum disorder: a qualitative study. Child Care Health Dev 43:536-545
Jones, Emily J H; Venema, Kaitlin; Earl, Rachel K et al. (2017) Infant social attention: an endophenotype of ASD-related traits? J Child Psychol Psychiatry 58:270-281
Webb, Sara Jane; Garrison, Michelle M; Bernier, Raphael et al. (2017) Severity of ASD symptoms and their correlation with the presence of copy number variations and exposure to first trimester ultrasound. Autism Res 10:472-484
Messinger, Daniel S; Young, Gregory S; Webb, Sara Jane et al. (2016) Commentary: sex difference differences? A reply to Constantino. Mol Autism 7:31
Navot, Noa; Jorgenson, Alicia Grattan; Vander Stoep, Ann et al. (2016) Family planning and family vision in mothers after diagnosis of a child with autism spectrum disorder. Autism 20:605-15
Jones, E J H; Venema, K; Earl, R et al. (2016) Reduced engagement with social stimuli in 6-month-old infants with later autism spectrum disorder: a longitudinal prospective study of infants at high familial risk. J Neurodev Disord 8:7
Neuhaus, Emily; Jones, Emily J H; Barnes, Karen et al. (2016) The Relationship Between Early Neural Responses to Emotional Faces at Age 3 and Later Autism and Anxiety Symptoms in Adolescents with Autism. J Autism Dev Disord 46:2450-63

Showing the most recent 10 out of 19 publications