Adults with histories of childhood abuse are particularly vulnerable to the development of stress- related psychopathology in adulthood. Although much research has focused on long-term negative sequel of childhood abuse across the lifespan of the abused child, surprisingly little research has examined the impact of childhood abuse across generations or the mechanisms of its trans-generational impact. Research demonstrates that children of mothers who were abused in childhood are at increased risk for stress related psychological disorders in adulthood and that mothers living in stressful environments are at increased risk for child maltreatment, impaired parenting and psychological disorders. Given the elevated levels of environmental stressors for families living in low-income, urban environments, it is particularly critical that we delineate how trauma is transmitted across generations in these populations. In order to address this gap in the literature, we propose to collect data on 400 low-income, urban, African American mothers and their 9-12 year old offspring. We will gather data at baseline and at 9 and 18 months post baseline. The proposed research will focus on maternal affect and affect regulation, and on maternal parenting and maternal stress response biomarkers as intermediate phenotypes that may contribute to increased intergenerational risk in children of maltreated mothers. We will also examine the role of child exposure to trauma, neighborhood violence and stress. We anticipate that this research will contribute significantly to the development of empirically grounded intervention and prevention approaches aimed at increasing resilience and decreasing risk in this population.
Children raised in environments of concentrated disadvantage are at very high risk for lifetime stress-related psychopathology and a factor that may amplify risk in this population is maternal history of childhood maltreatment. Children of mothers with a history of childhood maltreatment are at increased risk for stress-related psychological disorders promoting an intergenerational pattern of risk. The goal of this research is to inform the development of novel and effective assessment and treatment approaches in at-risk mothers and their children.
|Sharma, Sumeet; Powers, Abigail; Bradley, Bekh et al. (2016) Gene Ã— Environment Determinants of Stress- and Anxiety-Related Disorders. Annu Rev Psychol 67:239-61|
|Powers, Abigail; Almli, Lynn; Smith, Alicia et al. (2016) A genome-wide association study of emotion dysregulation: Evidence for interleukin 2 receptor alpha. J Psychiatr Res 83:195-202|
|Mandavia, Amar; Robinson, Gabriella G N; Bradley, Bekh et al. (2016) Exposure to Childhood Abuse and Later Substance Use: Indirect Effects of Emotion Dysregulation and Exposure to Trauma. J Trauma Stress 29:422-429|
|Lowe, Sarah R; Quinn, James W; Richards, Catherine A et al. (2016) Childhood trauma and neighborhood-level crime interact in predicting adult posttraumatic stress and major depression symptoms. Child Abuse Negl 51:212-22|
|Smearman, Erica L; Almli, Lynn M; Conneely, Karen N et al. (2016) Oxytocin Receptor Genetic and Epigenetic Variations: Association With Child Abuse and Adult Psychiatric Symptoms. Child Dev 87:122-34|
|Nugent, Nicole R; Goldberg, Amy; Uddin, Monica (2016) Topical Review: The Emerging Field of Epigenetics: Informing Models of Pediatric Trauma and Physical Health. J Pediatr Psychol 41:55-64|
|MacDonald, Kai; Thomas, Michael L; Sciolla, Andres F et al. (2016) Minimization of Childhood Maltreatment Is Common and Consequential: Results from a Large, Multinational Sample Using the Childhood Trauma Questionnaire. PLoS One 11:e0146058|
|Powers, Abigail; Fani, Negar; Cross, Dorthie et al. (2016) Childhood trauma, PTSD, and psychosis: Findings from a highly traumatized, minority sample. Child Abuse Negl 58:111-8|
|Goldstein, Brittany; Bradley, Bekh; Ressler, Kerry J et al. (2016) Associations Between Posttraumatic Stress Disorder, Emotion Dysregulation, and Alcohol Dependence Symptoms Among Inner City Females. J Clin Psychol :|
|Powers, Abigail; Michopoulos, Vasiliki; Conneely, Karen et al. (2016) Emotion Dysregulation and Inflammation in African-American Women with Type 2 Diabetes. Neural Plast 2016:8926840|
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