Autism is a common, impairing neurodevelopmental disorder involving deficits in social interaction and social communication. Oxytocin (OT) is a nine amino acid peptide produced in the hypothalamus and stored in the posterior pituitary. OT regulates the formation of close selective social bonds and has been implicated in the social dysfunction found in autism spectrum disorders (ASD). There has been a proliferation of recent research examining the effects of intranasal OT on human behavior, including suggestions for its use as a therapeutic for various psychopathologies involving social deficits, including ASD. Phase 2 trials for use of intranasal OT in autism are underway for children 12-18 years of age (Clinicaltrials.gov identifier: NCT01256060), and OT is already frequently prescribed in the United States to children with ASD. Alarmingly, our preliminary data in animal models show that while administration of intranasal OT has positive effects of social behavior in the short-term, long-term effects at some dosages are negative. Aside from our pilot study, there have been no long-term studies of chronic intranasal OT use in humans or in ANY animal model;that is what we propose to do in this study.
The aim of the current study is to examine the developmental effects of chronic intranasal OT administered to two animal models of selective social behavior (prairie voles and titi monkeys), as well as one mouse model of the social deficits of autism. In the rodent models, dosage, frequency, and age of administration will be varied. The immediate social effects of administration, as well as long-term effects on social behavior, repetitive behavior, and anxiety will be explored, as well as changes to the OT and vasopressin systems and functional neural changes in response to social stimuli. In titi monkeys, we will administer the dosage being used in clinical trials and examine the short-term and long-term effects on social behavior, repetitive behavior, and anxiety. Finally, we will examine changes to local cerebral glucose metabolism in titi monkeys treated with chronic intranasal OT or vehicle via PET imaging, with a focus on areas that produce or have receptors for OT.
Autism is a common, impairing neurodevelopmental disorder affecting 1 in 110 individuals. This proposal will investigate the long-term effects of chronic intranasal oxytocin, which has been proposed as a treatment for autism, in animal models.
|Freeman, Sara M; Rebout, Nancy; Bales, Karen L (2018) Effect of reward type on object discrimination learning in socially monogamous coppery titi monkeys (Callicebus cupreus). Am J Primatol 80:e22868|
|Seelke, Adele M; Rhine, Maya A; Khun, Konterri et al. (2018) Intranasal oxytocin reduces weight gain in diet-induced obese prairie voles. Physiol Behav 196:67-77|
|Kanthaswamy, Sree; Bales, Karen L (2018) Evaluating the genetic status of a closed colony of titi monkeys (Callicebus cupreus) using multigenerational pedigrees. J Med Primatol 47:139-141|
|Guoynes, C D; Simmons, T C; Downing, G M et al. (2018) Chronic Intranasal Oxytocin has Dose-dependent Effects on Central Oxytocin and Vasopressin Systems in Prairie Voles (Microtus ochrogaster). Neuroscience 369:292-302|
|Freeman, Sara M; Ngo, Julie; Singh, Bhavdeep et al. (2018) Effects of Chronic Oxytocin Administration and Diet Composition on Oxytocin and Vasopressin 1a Receptor Binding in the Rat Brain. Neuroscience 392:241-251|
|Larke, Rebecca H; Toubiana, Alice; Lindsay, Katrina A et al. (2017) Infant titi monkey behavior in the open field test and the effect of early adversity. Am J Primatol 79:|
|Perkeybile, Allison M; Bales, Karen L (2017) Intergenerational transmission of sociality: the role of parents in shaping social behavior in monogamous and non-monogamous species. J Exp Biol 220:114-123|
|Duchemin, Auriane; Seelke, Adele M H; Simmons, Trenton C et al. (2017) Localization of oxytocin receptors in the prairie vole (Microtus ochrogaster) neocortex. Neuroscience 348:201-211|
|Bales, Karen L (2017) Parenting in Animals. Curr Opin Psychol 15:93-98|
|Bales, Karen L; Saltzman, Wendy (2016) Fathering in rodents: Neurobiological substrates and consequences for offspring. Horm Behav 77:249-59|
Showing the most recent 10 out of 17 publications