This application addresses PA 10-006 Mechanisms, Models, Measurement, and Management in Pain Research (R01). The majority of children with cerebral palsy (CP) live with spasticity and spasticity-induced disabling chronic pain. One of the front-line treatments for spasticity involves surgically implanting a pump to intrathecally deliver baclofen (ITB). Doing so avoids the problems with orally administered baclofen but creates problems of its own including general surgical risks but also procedure specific issues such as cerebral spinal fluid (CSF) leaks and catheter malfunction leading to serious withdrawal complications. Thus, the procedure is not without risk, but on balance the evidence is tilted toward efficacy for spasticity outcomes by reducing spasticity. It is less clear, however, whether the chronic pain is also and always reduced. There are mixed and muddled results specific to pain outcomes;mixed because in some studies pain is reported to decrease but in others there is no apparent change, muddled because the majority of the studies are poorly designed with pain poorly measured and so the results are scientifically uncertain and clinically ambiguous. This specific problem - whether or not pain improves following ITB treatment - is part of a much broader general issue - whether we can use scientific advances from pain research to improve our clinical understanding of pain and disability among children with significant intellectual, motor, and communicative impairments associated with neurodevelopmental disorders. The overall goal of this application is to initiate a line of research with the primary objective of improving our scientific understanding of changes in chronic pain in response to treatment among children with significant neurodevelopmental disabilities. The specific purpose of this interdisciplinary translational proposal is to clarify the clinical ambiguity in pain outcomes in relation to ITB treatment by prospectively studying a sample of children with CP and spasticity before and after ITB implant. By doing so, we will be able to (a) examine in detail the relation between changes in spasticity and pain, (b) evaluate whether pain that persists even in the presence of reduced spasticity will be associated with poorer functional outcomes, and (c) empirically test whether treatment parameters associated with the pump implant, clinical features associated with CP, or physiological variables associated with pain, stress, and inflammation interact to influence pain specific treatment outcomes. To date, there has been no comprehensive study specific to chronic pain among children with CP treated with ITB pump implants. Considering the vulnerable clinical population for the proposed project, we believe there is an urgent imperative to try to make scientific advances from the 'bench'relevant to real-world pain and disability problems. Ultimately, the knowledge gain should transfer into a clinical decision making aide with respect to improving patient selection criteria and by informing patients, their families, and healthcare providers more completely about the full range of expected outcomes with respect to pain and function.

Public Health Relevance

Chronic pain associated with spasticity among children with cerebral palsy (CP) is a significant public health problem. Their spasticity is increasingly treate surgically by implanting intrathecal baclofen pumps for which it seems clear that although spasticity tends to respond (be reduced), a sizable subgroup of children continue to experience considerable pain and it is not clear whether this 'analgesic failure'is related to characteristic of their disability, psychosocial processes, treatment parameters associated with the pump, or individual differences in physiology relevant to pain, stress, and inflammation. The purpose of this study is discover whether there are clinically relevant marker variables that would improve our ability to predict who is more or less likely to be a 'pain responder'to ITB treatment.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project (R01)
Project #
5R01HD073126-02
Application #
8640964
Study Section
Behavioral Medicine, Interventions and Outcomes Study Section (BMIO)
Program Officer
Urv, Tiina K
Project Start
2013-04-01
Project End
2018-03-31
Budget Start
2014-04-01
Budget End
2015-03-31
Support Year
2
Fiscal Year
2014
Total Cost
$474,859
Indirect Cost
$102,797
Name
University of Minnesota Twin Cities
Department
Psychology
Type
Schools of Education
DUNS #
555917996
City
Minneapolis
State
MN
Country
United States
Zip Code
55455
Barney, Chantel C; Feyma, Timothy; Beisang, Arthur et al. (2015) Pain experience and expression in Rett syndrome: Subjective and objective measurement approaches. J Dev Phys Disabil 27:417-429
Barney, Chantel C; Hoch, John; Byiers, Breanne et al. (2015) A Case-controlled Investigation of Pain Experience and Sensory Function in Neuronal Ceroid Lipofuscinosis. Clin J Pain 31:998-1003
Symons, Frank J; Byiers, Breanne; Hoch, John et al. (2015) Infrared Thermal Analysis and Individual Differences in Skin Temperature Asymmetry in Rett Syndrome. Pediatr Neurol 53:169-72
Symons, Frank J; ElGhazi, Issam; Reilly, Brian G et al. (2015) Can biomarkers differentiate pain and no pain subgroups of nonverbal children with cerebral palsy? A preliminary investigation based on noninvasive saliva sampling. Pain Med 16:249-56
Byiers, Breanne J; Tervo, Raymond C; Feyma, Timothy J et al. (2014) Seizures and pain uncertainty associated with parenting stress and Rett syndrome. J Child Neurol 29:526-9
Shinde, Satomi K; Danov, Stacy; Chen, Chin-Chih et al. (2014) Convergent validity evidence for the Pain and Discomfort Scale (PADS) for pain assessment among adults with intellectual disability. Clin J Pain 30:536-43
Armitage, Ian M; Drakenberg, Torbjörn; Reilly, Brian (2013) Use of (113)Cd NMR to probe the native metal binding sites in metalloproteins: an overview. Met Ions Life Sci 11:117-44
Barney, Chantel C; Krach, Linda E; Rivard, Patrick F et al. (2013) Motor function predicts parent-reported musculoskeletal pain in children with cerebral palsy. Pain Res Manag 18:323-7
Symons, Frank J; Roberts, Jane E (2013) Biomarkers, behavior, and intellectual and developmental disabilities. Am J Intellect Dev Disabil 118:413-5
Symons, Frank J; Byiers, Breanne; Tervo, Raymond C et al. (2013) Parent-reported pain in Rett syndrome. Clin J Pain 29:744-6

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