Language impairment and communication difficulties are a hallmark of autism spectrum disorders. The central hypothesis underlying this proposal is that children on the autism spectrum manifest difficulties forming and accessing abstract representations and categorizing acoustic distinct but linguistically similar stimulus tokens into unitary objects. This difficulty has deep implications for their systems of word (lexical) processing and representation: attention to (irrelevant) acoustic detail prevents fast/successful activation of abstract lexical representations. This hypothesis will be probed in school-age children (6-10 years) on the autism spectrum (and age-matched, NVIQ-matched neurotypical controls), using the brain recording technology of magnetoencephalography (MEG) to gain spectral, temporal and spatial insights from paradigms probing lexical access, word difference detection and variants of priming. It is further hypothesized that--because failure to abstract/attention to extraneous impedes lexical access--reduction of extraneous detail (e.g. band-pass filtering) might improve abstraction/categorization by making different tokens of the same word easier to recognize as sharing an abstract representation. If successful in unifying disparate percepts of acoustically-different but lexically-identical stimuli into categorical representations/abstract representations, this manipulation might pave the way for future therapeutic options.

Public Health Relevance

This project proposes to use magnetoencepholography (MEG) to explore the nature of lexical processing in Autism Spectrum Disorders (ASD). The general hypothesis is that failure to abstract/reliance on compensatory mechanisms of episodic memory in the ASD brain leads to difficulties in lexical processing, such that acoustically distinc instances of the same word are treated as distinct objects. Successful identification of deficits arising from failure to categorize sounds and words properly might pave the way for therapeutic options.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Project (R01)
Project #
1R01HD073258-01
Application #
8343692
Study Section
Child Psychopathology and Developmental Disabilities Study Section (CPDD)
Program Officer
Kau, Alice S
Project Start
2012-08-13
Project End
2017-05-31
Budget Start
2012-08-13
Budget End
2013-05-31
Support Year
1
Fiscal Year
2012
Total Cost
$321,156
Indirect Cost
$71,281
Name
University of Pennsylvania
Department
Miscellaneous
Type
Schools of Arts and Sciences
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Brennan, Jonathan; Lignos, Constantine; Embick, David et al. (2014) Spectro-temporal correlates of lexical access during auditory lexical decision. Brain Lang 133:39-46