Limbic-based """"""""bottom-up"""""""" systems characterized by heightened reactivity to motivational stimuli and rewards mature rapidly from early adolescence, while prefrontally-organized """"""""top- down"""""""" systems that enable more effective cognitive control and judgment mature more slowly (Casey &Jones, 2010). This mismatch has been proposed as a key contributor to health risk behavior among adolescents, which is of critical importance because: (1) risk behaviors are the leading cause of morbidity and mortality in this age group, including diseases arising from unprotected sexual activity and casualties arising from reckless behavior (including driving fatalities and serious injuries);(2) it is the peak age for the onset f a wide range of risk behavior patterns with potential long-term consequences, including substance use and abuse, and delinquency. The developmental maturity mismatch hypothesis, however, has not been directly tested in relation to risk behavior at a level sufficient to inform this critcal health area (Pfeifer &Allen, 2012). The primary aim of the proposed research is to understand the behavioral, cognitive, and neural bases of risk taking, through integrated analyses of age differences, developmental trajectories, and individual differences in psychosocial, neurocognitive and neural imaging assessments.

Public Health Relevance

The expected outcomes of the proposed research will have an important positive impact in that they will provide information about the developmental mechanisms contributing to adolescent health risk behaviors. This information is essential for developing new preventive interventions that can reduce the population health burden arising from behavioral misadventure in the adolescent and early adult years. Identifying the psychosocial, neurocognitive, and neural mechanisms that contribute to health risk behaviors holds promise for improving our ability to effectively address the significant costs of behavioral misadventure, the leading source of population health risks during adolescence.

National Institute of Health (NIH)
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Research Project (R01)
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Psychosocial Development, Risk and Prevention Study Section (PDRP)
Program Officer
Freund, Lisa S
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University of Michigan Ann Arbor
Biostatistics & Other Math Sci
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Ann Arbor
United States
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Thomason, Moriah E; Marusak, Hilary A (2017) Toward understanding the impact of trauma on the early developing human brain. Neuroscience 342:55-67
Marusak, Hilary A; Furman, Daniella J; Kuruvadi, Nisha et al. (2015) Amygdala responses to salient social cues vary with oxytocin receptor genotype in youth. Neuropsychologia 79:1-9
Thomason, Moriah E; Marusak, Hilary A; Tocco, Maria A et al. (2015) Altered amygdala connectivity in urban youth exposed to trauma. Soc Cogn Affect Neurosci 10:1460-8