How do stressful experiences that happen in early life have such powerful direct effects on poor health decades later? When and how do these experiences become biologically embedded? To address this question, we are following a 1994-95 birth cohort of 2,232 twins (the E-Risk Study). The cohort is well- characterized, environmentally and phenotypically, with assessments at birth, 2,5,7,10,12, and 18 years, and has a dedicated biobank. Our research focuses on exposure to violence, one of the most common and severe sources of human stress. We begin by compiling cumulative dossiers of violence exposure in childhood and adolescence, including child maltreatment, sexual abuse, domestic violence, peer victimization, dating violence, and conventional crime. We then test the hypothesis that young people who are exposed to violence in childhood and adolescence will, by young adulthood, show compromised neuropsychological functioning, telomere erosion, and differential expression and epigenetic regulation of genes involved in the coordination of the stress response and the regulation of immune and inflammatory reactions. A key need in this research is for violence exposure to be disentangled from associated risk factors, including poverty, parents'mental health, and genetic liability. Analyses with the E-Risk cohort will isolat these effects of violence exposure by (a) comparing twins who are discordant for violence exposure on their psychobiological outcomes, (b) studying within-individual changes in psychobiological outcomes, using each child as his or her own control, and ultimately (c) identifying protective factors that mitigate biological embedding of exposure to violence. The E- Risk Study will be the first major developmental-longitudinal cohort study to bring together detailed assessments of multiple kinds of exposure to violence and multiple stress biomarkers, in order to characterize the mechanisms through which violence-exposed children may acquire lasting vulnerability to disease.
The proposed research aims to uncover the genomic, biological and behavioral mechanisms that account for the enduring disease vulnerability of violence-exposed children and adolescents and to suggest effective interventions before onset of clinical disease.
|Matthews, T; Danese, A; Gregory, A M et al. (2017) Sleeping with one eye open: loneliness and sleep quality in young adults. Psychol Med 47:2177-2186|
|Schaefer, Jonathan D; Scult, Matthew A; Caspi, Avshalom et al. (2017) Is low cognitive functioning a predictor or consequence of major depressive disorder? A test in two longitudinal birth cohorts. Dev Psychopathol :1-15|
|Danese, Andrea; Moffitt, Terrie E; Arseneault, Louise et al. (2017) The Origins of Cognitive Deficits in Victimized Children: Implications for Neuroscientists and Clinicians. Am J Psychiatry 174:349-361|
|Gregory, Alice M; Agnew-Blais, Jessica C; Matthews, Timothy et al. (2017) ADHD and Sleep Quality: Longitudinal Analyses From Childhood to Early Adulthood in a Twin Cohort. J Clin Child Adolesc Psychol 46:284-294|
|Williams, M J A; Milne, B J; Ambler, A et al. (2017) Childhood body mass index and endothelial dysfunction evaluated by peripheral arterial tonometry in early midlife. Int J Obes (Lond) 41:1355-1360|
|Wertz, Jasmin; Nottingham, Kate; Agnew-Blais, Jessica et al. (2016) Parental monitoring and knowledge: Testing bidirectional associations with youths' antisocial behavior. Dev Psychopathol 28:623-38|
|Newbury, Joanne; Arseneault, Louise; Caspi, Avshalom et al. (2016) Why Are Children in Urban Neighborhoods at Increased Risk for Psychotic Symptoms? Findings From a UK Longitudinal Cohort Study. Schizophr Bull 42:1372-1383|
|Goldman-Mellor, Sidra; Caspi, Avshalom; Arseneault, Louise et al. (2016) Committed to work but vulnerable: self-perceptions and mental health in NEET 18-year olds from a contemporary British cohort. J Child Psychol Psychiatry 57:196-203|
|Wertz, Jasmin; Zavos, Helena M S; Matthews, Timothy et al. (2016) Etiology of Pervasive Versus Situational Antisocial Behaviors: A Multi-Informant Longitudinal Cohort Study. Child Dev 87:312-25|
|Matthews, Timothy; Danese, Andrea; Wertz, Jasmin et al. (2016) Social isolation, loneliness and depression in young adulthood: a behavioural genetic analysis. Soc Psychiatry Psychiatr Epidemiol 51:339-48|
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