The long-term objective of this project is to develop powerful and computationally-efficient statistical methods for statistical modeling of high-dimensional genomic data motivated by important biological problems and experiments.
The specific aims of the current project include developing novel survival analysis methods to model the heterogeneity in both patients and biomarkers in genomic studies and developing robust survival analysis methods to analyze high-dimensional genomic data. The proposed methods hinge on a novel integration of methods in high-dimensional data analysis, theory in statistical learning and methods in human genomics. The project will also investigate the robustness, power and efficiencies of these methods and compare them with existing methods. Results from applying the methods to studies of ovarian cancer, lung cancer, brain cancer will help ensure that maximal information is obtained from the high-throughput experiments conducted by our collaborators as well as data that are publicly available. Software will be made available through Bioconductor to ensure that the scientific community benefits from the methods developed.

Public Health Relevance

The last decade of advanced laboratory techniques has had a profound impact on genomic research, however, the development of corresponding statistical methods to analyze the data has not been in the same pace. This project aims to develop, evaluate, and disseminate powerful and computationally-efficient statistical methods to model the heterogeneity in both patients and biomarkers in genomic studies. We believe our proposed methods can help scientific community turn valuable high-throughput measurements into meaningful results.

Agency
National Institute of Health (NIH)
Institute
National Human Genome Research Institute (NHGRI)
Type
Research Project (R01)
Project #
1R01HG007377-01A1
Application #
8696520
Study Section
Biostatistical Methods and Research Design Study Section (BMRD)
Program Officer
Ramos, Erin
Project Start
2014-06-04
Project End
2018-03-31
Budget Start
2014-06-04
Budget End
2015-03-31
Support Year
1
Fiscal Year
2014
Total Cost
$255,295
Indirect Cost
$80,295
Name
University of Wisconsin Madison
Department
Biostatistics & Other Math Sci
Type
Schools of Medicine
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715