Efforts in our laboratory to construct the alkaloid germine, present as various esters in the cordioactive vinca alkaloids have made considerable progress during the last few years. We have constructed two sections of the molecule and intend to complete the entire six-ring system by joining them in such a fashion that the asymmetry in one half controls that in the other, eventually resulting in the correct arangement of the sixteen asymmetric center.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
2R01HL025635-07
Application #
3338159
Study Section
Medicinal Chemistry Study Section (MCHA)
Project Start
1980-04-01
Project End
1989-03-31
Budget Start
1986-04-01
Budget End
1987-03-31
Support Year
7
Fiscal Year
1986
Total Cost
Indirect Cost
Name
Columbia University (N.Y.)
Department
Type
Graduate Schools
DUNS #
064931884
City
New York
State
NY
Country
United States
Zip Code
10027