Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL031809-14
Application #
2216904
Study Section
Allergy and Immunology Study Section (ALY)
Project Start
1983-07-01
Project End
2000-05-31
Budget Start
1996-06-01
Budget End
1997-05-31
Support Year
14
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of California San Francisco
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
073133571
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Huang, Mei-Chuan; Patel, Kalpesh; Taub, Dennis D et al. (2010) Human CD4- 8- T cells are a distinctive immunoregulatory subset. FASEB J 24:2558-66
Goetzl, Edward J; Huang, Mei-Chuan; Kon, Junko et al. (2010) Gender specificity of altered human immune cytokine profiles in aging. FASEB J 24:3580-9
Yeh, Che-Chung; Li, Hongzhe; Malhotra, Deepak et al. (2009) Sphingolipid signaling and treatment during remodeling of the uninfarcted ventricular wall after myocardial infarction. Am J Physiol Heart Circ Physiol 296:H1193-9
Liao, Jia-Jun; Huang, Mei-Chuan; Fast, Katharine et al. (2009) Immunosuppressive human anti-lymphocyte autoantibodies specific for the type 1 sphingosine 1-phosphate receptor. FASEB J 23:1786-96
Goetzl, Edward J; Liao, Jia-Jun; Huang, Mei-Chuan (2008) Regulation of the roles of sphingosine 1-phosphate and its type 1 G protein-coupled receptor in T cell immunity and autoimmunity. Biochim Biophys Acta 1781:503-7
Huang, Mei-Chuan; Liao, Jia-Jun; Bonasera, Stephen et al. (2008) Nuclear factor-kappaB-dependent reversal of aging-induced alterations in T cell cytokines. FASEB J 22:2142-50
Liao, Jia-Jun; Huang, Mei-Chuan; Goetzl, Edward J (2007) Cutting edge: Alternative signaling of Th17 cell development by sphingosine 1-phosphate. J Immunol 178:5425-8
Goetzl, Edward J; Wang, Wengang; McGiffert, Christine et al. (2007) Sphingosine 1-phosphate as an intracellular messenger and extracellular mediator in immunity. Acta Paediatr Suppl 96:49-52
Wang, Wengang; Huang, Mei-Chuan; Goetzl, Edward J (2007) Type 1 sphingosine 1-phosphate G protein-coupled receptor (S1P1) mediation of enhanced IL-4 generation by CD4 T cells from S1P1 transgenic mice. J Immunol 178:4885-90
Huang, Mei-Chuan; Watson, Susan R; Liao, Jia-Jun et al. (2007) Th17 augmentation in OTII TCR plus T cell-selective type 1 sphingosine 1-phosphate receptor double transgenic mice. J Immunol 178:6806-13

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