These proposed studies will provide information on the control of renal and systemic hemodynamics during normal pregnancy and in pregnancies which are compromised by hypertension and proteinuria (pre-eclampsia) and underlying renal disease. It is intended, specifically, to investigate the factors which initiate the gestational rise in GFR, with particular reference to the renal vasodilator dopamine and the role of extra-cellular fluid volume expansion. Control of GFR in late pregnancy will also be investigated, with particular reference to tupulo-glomerular feedback control of GFR and to renal autoregulation. In addition, neurohumoral control of renal and systemic hemodynamics in mid- and late pregnancy will be evaluated with particular reference to the role of the sympathetic nervous system. The effect of dietary restriction of essential fatty acids, magnesium and calcicum in the pathogenesis of pre-eclampsia will also be investigated. Finally, studies will be performed to assess the effect of superimposition of pregnancy on underlying renal disease with regard to both the influence of pregnancy on the progression of the disease process and the effect of underlying renal disease on the renal response to gestation. The effects of repetitive pregnancy as a stimulus to prolonged nephron hyperfiltration will also be investigated, when superimposed on other hyperfiltration states. These studies will be performed using the """"""""in-vivo"""""""" techniques of kidney micropuncture (under anesthesia) and in the awake, chronically catheterized rat.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
2R01HL031933-03
Application #
3343086
Study Section
General Medicine B Study Section (GMB)
Project Start
1983-07-01
Project End
1988-06-30
Budget Start
1985-07-01
Budget End
1986-06-30
Support Year
3
Fiscal Year
1985
Total Cost
Indirect Cost
Name
University of California San Diego
Department
Type
Schools of Medicine
DUNS #
077758407
City
La Jolla
State
CA
Country
United States
Zip Code
92093
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Smith, Cheryl A; Santymire, Beth; Erdely, Aaron et al. (2010) Renal nitric oxide production in rat pregnancy: role of constitutive nitric oxide synthases. Am J Physiol Renal Physiol 299:F830-6
Podjarny, Eduardo; Losonczy, Gyorgy; Baylis, Chris (2004) Animal models of preeclampsia. Semin Nephrol 24:596-606
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Podjarny, E; Baylis, C; Losonczy, G (1999) Animal models of preeclampsia. Semin Perinatol 23:2-13
Kriston, T; Venuto, R C; Baylis, C et al. (1999) Hemodynamic and renal effects of U-46619, a TXA2/PGH2 analog, in late-pregnant rats. Am J Physiol 276:R831-7
Baylis, C (1999) Glomerular filtration rate in normal and abnormal pregnancies. Semin Nephrol 19:133-9
Mahaney, J; Felton, C; Taylor, D et al. (1998) Renal cortical Na+-K+-ATPase activity and abundance is decreased in normal pregnant rats. Am J Physiol 275:F812-7
Masilamani, S; Hobbs, G R; Baylis, C (1998) The acute pressure natriuresis response blunted and the blood pressure response reset in the normal pregnant rat. Am J Obstet Gynecol 179:486-91
Baylis, C; Beinder, E; Suto, T et al. (1998) Recent insights into the roles of nitric oxide and renin-angiotensin in the pathophysiology of preeclamptic pregnancy. Semin Nephrol 18:208-30

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