The specific aims of the research described in this application are: (1) To determine the functional capacity of immature coronary collaterals (thinwalled vessels without muscular coats) immediately after coronary artery occlusion and during the first few weeks of occlusion. (2) To determine the functional capacity of mature coronary collaterals (vessels that have developed a muscular wall and have autoregulatory capacity) during the months after coronary artery occlusion. (3) To determine the time necessary for development from immature to mature forms of coronary collateral vessels after the onset of coronary occlusion. (4) To quantitate the morphologic changes occurring in coronary collateral vessels in both immature and mature forms. (5) To determine the effects of various interventions on coronary collateral flow, regional myocardial function and coronary collateral vessel morphometry. (6) To determine if there is an active growth process in the development of coronary collateral vessels using triated thymidine. These studies of the functional and structural significance of the coronary collateral circulation are designed to examine three hypotheses, i.e., (1) when coronary collaterals remodel themselves into arterioles or small muscular arteries, they becomes functionally significant; (2) there is viable functional tissue in bed at risk after coronary occlusion; and (3) the rate of growth of coronary collaterals, the mechanical function of the bed at risk and the amount of viable functional tissue in the bed at risk after coronary occlusion are augmented by exercise and drugs.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL032670-02
Application #
3344073
Study Section
Cardiovascular Study Section (CVA)
Project Start
1984-08-01
Project End
1989-07-31
Budget Start
1985-08-01
Budget End
1986-07-31
Support Year
2
Fiscal Year
1985
Total Cost
Indirect Cost
Name
University of California San Diego
Department
Type
Schools of Medicine
DUNS #
077758407
City
La Jolla
State
CA
Country
United States
Zip Code
92093
White, F C; Bloor, C M; McKirnan, M D et al. (1998) Exercise training in swine promotes growth of arteriolar bed and capillary angiogenesis in heart. J Appl Physiol 85:1160-8
Bloor, C M; Nimmo, L; McKirnan, M D et al. (1997) Increased gene expression of plasminogen activators and inhibitors in left ventricular hypertrophy. Mol Cell Biochem 176:265-71
Knoepfler, P S; Bloor, C M; Carroll, S M (1995) Urokinase plasminogen activator activity is increased in the myocardium during coronary artery occlusion. J Mol Cell Cardiol 27:1317-24
White, F C; Carroll, S M; Kamps, M P (1995) VEGF mRNA is reversibly stabilized by hypoxia and persistently stabilized in VEGF-overexpressing human tumor cell lines. Growth Factors 12:289-301
McKirnan, M D; Bloor, C M (1994) Clinical significance of coronary vascular adaptations to exercise training. Med Sci Sports Exerc 26:1262-8
Gerritsen, M E; Bloor, C M (1993) Endothelial cell gene expression in response to injury. FASEB J 7:523-32
Carroll, S M; White, F C; Roth, D M et al. (1993) Heparin accelerates coronary collateral development in a porcine model of coronary artery occlusion. Circulation 88:198-207
White, F C; Bloor, C M (1992) Coronary vascular remodeling and coronary resistance during chronic ischemia. Am J Cardiovasc Pathol 4:193-202
White, F C; Nakatani, Y; Nimmo, L et al. (1992) Compensatory angiogenesis during progressive right ventricular hypertrophy. Am J Cardiovasc Pathol 4:51-68
White, F C; Carroll, S M; Magnet, A et al. (1992) Coronary collateral development in swine after coronary artery occlusion. Circ Res 71:1490-500

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