This proposal is to study the efficaciousness of a large stroke volume (100 ml) small elliptical heart orothotopically placed in 50 kg animals. This work includes hemodynamics, blood-material interaction, pathophysiology, durability, and reliability, and post mortem evaluation. These studies will be conducted by implanting this innovative device into a series of calves (short-term studies) and adult, nonrowing sheep (long-term studies). The hemodynamics will be monitored in the short-term experiments utilizing open-port catheters and both series will be studied with the nonnivasive cardiac output and diagnostic monitor during rest and exercise. Standard blood chemistries and cellular levels will be routinely monitored. Organ function will also be evaluated. At the termination of the experiments, detailed autopsies will be conducted on both the animals and the devices. The derived data will be analyzed and compared with data obtained from previous JARVIK-7 heart implant studies. Placement of a 100 cc stroke volume elliptical TAH in 50 kg recipients without compromising other organ function makes possible the application of this blood pump to a large segment of the human population with end-stage heart failure, who possess thoracic dimensions too small to accommodate the JARVIK-7 total artificial heart. Fabrication is made easier and more reliable by the simple design of the ventricular housing and allows the future application of injection molding to the manufacture of this blood pump. This two-year project will provide the data regarding pumping capabilities, regulation, blood compatibility, and durability, which is necessary for perfecting and characterizing this new total artificial heart. Long-term use of this more efficient design will verify its superior utilization of the available thoracic space when the natural heart is excised without harming surrounding structures. This new elliptical total artificial heart opens up new areas of research and clinical application of mechanical replacement of the natural heart.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL032816-06
Application #
3344312
Study Section
Surgery and Bioengineering Study Section (SB)
Project Start
1985-09-30
Project End
1993-03-31
Budget Start
1991-04-01
Budget End
1992-03-31
Support Year
6
Fiscal Year
1991
Total Cost
Indirect Cost
Name
University of Utah
Department
Type
Organized Research Units
DUNS #
City
Salt Lake City
State
UT
Country
United States
Zip Code
84112
Pantalos, G M; Kim, C H; Flatau, A (1996) Variation in artificial heart acceleration and sound production with prosthetic valve selection in vitro. Int J Artif Organs 19:181-8
Robison, P D; Pantalos, G M; Long Jr, J W et al. (1993) Measurement of oxygen consumption and arterial-venous oxygen saturation following total artificial heart implantation. Int J Artif Organs 16:135-40
Rowles, J R; Mortimer, B J; Olsen, D B (1993) Ventricular assist and total artificial heart devices for clinical use in 1993. ASAIO J 39:840-55
Nojiri, C; Okano, T; Koyanagi, H et al. (1992) In vivo protein adsorption on polymers: visualization of adsorbed proteins on vascular implants in dogs. J Biomater Sci Polym Ed 4:75-88
White, R K; Bliss, R S; Everett, S D et al. (1991) Comparison of microsphere and intraoperative quantitation of bronchial blood flow. ASAIO Trans 37:M507-9
Everett, S D; Pantalos, G M; Goldenberg, I F et al. (1991) Calves chronically implanted with a total artificial heart as a pharmacological model. Int J Artif Organs 14:775-80
Nojiri, C; Okano, T; Jacobs, H A et al. (1990) Blood compatibility of PEO grafted polyurethane and HEMA/styrene block copolymer surfaces. J Biomed Mater Res 24:1151-71
Nojiri, C; Park, K D; Grainger, D W et al. (1990) In vivo nonthrombogenicity of heparin immobilized polymer surfaces. ASAIO Trans 36:M168-72
Shaw, W J; Pantalos, G M; Everett, S et al. (1990) Factors influencing the accuracy of the cardiac output monitoring and diagnostic unit for pneumatic artificial hearts. ASAIO Trans 36:M264-8
Dew, P A; Pantalos, G M; Holfert, J W et al. (1990) Design mediated thrombus reduction in the Utah-100 total artificial heart. ASAIO Trans 36:M230-4

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