The plan is to continue investigation of determinants of cardiovascular disease (CVD) in a large, prospective cohort study of long duration, comprised of 121,700 US female registered nurses who have been followed since 1976 and are currently age 51-76 years. Continued follow-up will permit evaluation of a number of new and timely hypotheses regarding dietary and hormonal risk factors for coronary heart disease (CHD) as well as ischemic and hemorrhagic stroke. In addition, follow-up of two new and important endpoints, sudden cardiac death (SCD) and congestive heart failure (CHF), will be established, allowing them to examine the effect of atherogenic risk factors, physical activity and weight change on risk of SCD, as well as implement a methodology for confirming CHF. The Nurses' Health Study was begun in 1976 to study risk factors for breast cancer. In 1979, funding for risk factors of CVD was secured. Biennial mailed questionnaires gather detailed, updated information about a large number of exposures, including diet, smoking physical activity, postmenopausal hormone use, and psychosocial and behavioral factors. Incident reports of myocardial infarction and stroke are confirmed an classified by review of medical records, and similar procedures will be extended to confirm CHF and SCD. Fatal CVD events are documented by death certificates and confirmed by review of hospital medical records, autopsy reports and interviews with next of kin. Mortality follow-up exceeds 98 percent. The large size, prospective design, high follow-up rates, detailed and reliable long-term exposure and outcome information, and the availability of blood specimens on a large subgroup, combined with the relatively low cost, make this cohort a valuable and unique resource to study nutritional, hormonal and behavioral determinants of CVD in women. Continued funding of this grant will provide important new information about risk factors for CHD, stroke, SCD and CHF in this population of women who are now entering the age where CVD becomes the leading killer.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Research Project (R01)
Project #
Application #
Study Section
Special Emphasis Panel (ZRG4-HPD (06))
Program Officer
Silsbee, Lorraine M
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Brigham and Women's Hospital
United States
Zip Code
Patel, Ravi B; Moorthy, M V; Chiuve, Stephanie E et al. (2017) Hemoglobin A1c levels and risk of sudden cardiac death: A nested case-control study. Heart Rhythm 14:72-78
Justice, Anne E (see original citation for additional authors) (2017) Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits. Nat Commun 8:14977
Sotos-Prieto, Mercedes; Bhupathiraju, Shilpa N; Mattei, Josiemer et al. (2017) Association of Changes in Diet Quality with Total and Cause-Specific Mortality. N Engl J Med 377:143-153
Wang, Tiange; Huang, Tao; Heianza, Yoriko et al. (2017) Genetic Susceptibility, Change in Physical Activity, and Long-term Weight Gain. Diabetes 66:2704-2712
Huang, Tao; Zheng, Yan; Hruby, Adela et al. (2017) Dietary Protein Modifies the Effect of the MC4R Genotype on 2-Year Changes in Appetite and Food Craving: The POUNDS Lost Trial. J Nutr 147:439-444
Chang, Shun-Chiao; Glymour, Maria; Cornelis, Marilyn et al. (2017) Social Integration and Reduced Risk of Coronary Heart Disease in Women: The Role of Lifestyle Behaviors. Circ Res 120:1927-1937
Guasch-Ferré, Marta; Liu, Xiaoran; Malik, Vasanti S et al. (2017) Nut Consumption and Risk of Cardiovascular Disease. J Am Coll Cardiol 70:2519-2532
Heianza, Yoriko; Sun, Dianjianyi; Wang, Tiange et al. (2017) Starch Digestion-Related Amylase Genetic Variant Affects 2-Year Changes in Adiposity in Response to Weight-Loss Diets: The POUNDS Lost Trial. Diabetes 66:2416-2423
Lv, Jun; Yu, Canqing; Guo, Yu et al. (2017) Gallstone Disease and the Risk of Type 2 Diabetes. Sci Rep 7:15853
Qi, Lu; Ma, Wenjie; Heianza, Yoriko et al. (2017) Independent and Synergistic Associations of Biomarkers of Vitamin D Status With Risk of Coronary Heart Disease. Arterioscler Thromb Vasc Biol 37:2204-2212

Showing the most recent 10 out of 376 publications