This population-based study proposes to continue the examination of changing trends in the incidence, in-hospital, and long-term survival rates of acute myocardial infarction (AMI) and out-of hospital deaths due to coronary heart disease (CHD) in residents of the Worcester, MA, metropolitan area. The objectives of this observational study are to examine contemporary (2009 and 2011), as compared to prior (1975-2007), trends in the annual attack rates of AMI, hospital and post-discharge survival rates, management practices, and out-of-hospital deaths attributed to CHD. To accomplish these and several secondary study objectives, the proposed investigation will be carried out in the 11 acute care general hospitals providing care for residents of the Worcester, MA, metropolitan area (2000 census count=478,000). This study will utilize and extend previous approaches used in the conduct of this investigation. All new (incident) and recurrent episodes of definite AMI occurring in greater Worcester residents during 2009 and 2011 will be identified from discharge diagnostic printouts obtained from all metropolitan Worcester hospitals. The medical records of greater Worcester residents will be individually reviewed for validation purposes according to pre-established diagnostic criteria for AMI. Abstraction of the medical records of patients satisfying the diagnostic and geographic eligibility criteria will be carried out by trained physicians and nurses with the recording of demographic, clinical, and treatment related data. A review of records for additional hospitalizations and a search of death certificates will be carried out to examine the long-term survival status of discharged hospital patients from each of the proposed study years, as well as those identified previously, through 2012. Death certificates will be reviewed to identify cases of out-of-hospital deaths attributed to CHD occurring during 2009 and 2011. The results of this community-wide investigation will provide important insights from a more than 35 year (1975-2011) vantage point about the magnitude of, mortality from, and treatment approaches used in the management of the nation's leading cause of death as it affects residents of a large New England metropolitan area.

Public Health Relevance

The proposed community-based research project will provide insights to the changing magnitude of, and outcomes associated with, heart attacks in residents of a large central New England community. The results of this investigation will also provide contemporary data on how patients who experience heart attacks in the community are treated by physicians.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
3R01HL035434-28S1
Application #
8639183
Study Section
Cardiovascular and Sleep Epidemiology (CASE)
Program Officer
Ni, Hanyu
Project Start
1986-12-01
Project End
2015-06-30
Budget Start
2013-04-01
Budget End
2013-06-30
Support Year
28
Fiscal Year
2013
Total Cost
$26,457
Indirect Cost
$10,519
Name
University of Massachusetts Medical School Worcester
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
603847393
City
Worcester
State
MA
Country
United States
Zip Code
01655
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Chen, Han-Yang; McManus, David D; Saczynski, Jane S et al. (2014) Characteristics, treatment practices, and in-hospital outcomes of older adults hospitalized with acute myocardial infarction. J Am Geriatr Soc 62:1451-9
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Tisminetzky, Mayra; McManus, David D; Gore, Joel M et al. (2014) 30-year trends in patient characteristics, treatment practices, and long-term outcomes of adults aged 35 to 54 years hospitalized with acute myocardial infarction. Am J Cardiol 113:1137-41
Xiao, Rui S; Kroll-Desrosiers, Aimee R; Goldberg, Robert J et al. (2014) The impact of sleep, stress, and depression on postpartum weight retention: a systematic review. J Psychosom Res 77:351-8
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Tjia, Jennifer; Allison, Jeroan; Saczynski, Jane S et al. (2013) Encouraging trends in acute myocardial infarction survival in the oldest old. Am J Med 126:798-804
Mick, Eric; McManus, David D; Goldberg, Robert J (2013) Meta-analysis of increased heart rate and blood pressure associated with CNS stimulant treatment of ADHD in adults. Eur Neuropsychopharmacol 23:534-41

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