Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL041939-08
Application #
2220215
Study Section
Lung Biology and Pathology Study Section (LBPA)
Project Start
1988-09-30
Project End
1998-03-31
Budget Start
1996-04-01
Budget End
1997-03-31
Support Year
8
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Pennsylvania
Department
Physiology
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Chatterjee, Shampa; Nieman, Gary F; Christie, Jason D et al. (2014) Shear stress-related mechanosignaling with lung ischemia: lessons from basic research can inform lung transplantation. Am J Physiol Lung Cell Mol Physiol 307:L668-80
Chatterjee, Shampa; Chapman, Kenneth E; Fisher, Aron B (2008) Lung ischemia: a model for endothelial mechanotransduction. Cell Biochem Biophys 52:125-38
Fisher, A B (2004) Reactive oxygen species and cell signaling with lung ischemia. Undersea Hyperb Med 31:97-103
Fisher, Aron B; Al-Mehdi, Abu B; Manevich, Yefim (2002) Shear stress and endothelial cell activation. Crit Care Med 30:S192-7
Al-Mehdi, A B; Zhao, G; Tozawa, K et al. (2000) Depolarization-associated iron release with abrupt reduction in pulmonary endothelial shear stress in situ. Antioxid Redox Signal 2:335-45
Fisher, A B; Al-Mehdi, A B; Muzykantov, V (1999) Activation of endothelial NADPH oxidase as the source of a reactive oxygen species in lung ischemia. Chest 116:25S-26S
Tozawa, K; al-Mehdi, A B; Muzykantov, V et al. (1999) In situ imaging of intracellular calcium with ischemia in lung subpleural microvascular endothelial cells. Antioxid Redox Signal 1:145-54
Wei, Z; Costa, K; Al-Mehdi, A B et al. (1999) Simulated ischemia in flow-adapted endothelial cells leads to generation of reactive oxygen species and cell signaling. Circ Res 85:682-9
Atochina, E N; Balyasnikova, I V; Danilov, S M et al. (1998) Immunotargeting of catalase to ACE or ICAM-1 protects perfused rat lungs against oxidative stress. Am J Physiol 275:L806-17
Al-Mehdi, A B; Zhao, G; Fisher, A B (1998) ATP-independent membrane depolarization with ischemia in the oxygen-ventilated isolated rat lung. Am J Respir Cell Mol Biol 18:653-61

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