Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
2R01HL046215-05A1
Application #
2222744
Study Section
Hematology Subcommittee 2 (HEM)
Project Start
1992-02-01
Project End
2000-05-31
Budget Start
1996-07-15
Budget End
1997-05-31
Support Year
5
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Emory University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
042250712
City
Atlanta
State
GA
Country
United States
Zip Code
30322
Parker, Ernest T; Healey, John F; Barrow, Rachel T et al. (2004) Reduction of the inhibitory antibody response to human factor VIII in hemophilia A mice by mutagenesis of the A2 domain B-cell epitope. Blood 104:704-10
van den Brink, Edward N; Bril, Wendy S; Turenhout, Ellen A M et al. (2002) Two classes of germline genes both derived from the V(H)1 family direct the formation of human antibodies that recognize distinct antigenic sites in the C2 domain of factor VIII. Blood 99:2828-34
Wu, H; Reding, M; Qian, J et al. (2001) Mechanism of the immune response to human factor VIII in murine hemophilia A. Thromb Haemost 85:125-33
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Lian, F; He, L; Colwell, N S et al. (2001) Anticoagulant activities of a monoclonal antibody that binds to exosite II of thrombin. Biochemistry 40:8508-13
Barrow, R T; Healey, J F; Gailani, D et al. (2000) Reduction of the antigenicity of factor VIII toward complex inhibitory antibody plasmas using multiply-substituted hybrid human/porcine factor VIII molecules. Blood 95:564-8
Lollar, P (1999) Characterization of factor VIII B-cell inhibitory epitopes. Thromb Haemost 82:505-8
Healey, J F; Barrow, R T; Tamim, H M et al. (1998) Residues Glu2181-Val2243 contain a major determinant of the inhibitory epitope in the C2 domain of human factor VIII. Blood 92:3701-9
Lubin, I M; Healey, J F; Barrow, R T et al. (1997) Analysis of the human factor VIII A2 inhibitor epitope by alanine scanning mutagenesis. J Biol Chem 272:30191-5
Lollar, P (1997) Analysis of factor VIII inhibitors using hybrid human/porcine factor VIII. Thromb Haemost 78:647-51

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