Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL047000-04
Application #
2223318
Study Section
Hematology Subcommittee 2 (HEM)
Project Start
1991-09-01
Project End
1996-08-31
Budget Start
1994-09-01
Budget End
1996-08-31
Support Year
4
Fiscal Year
1994
Total Cost
Indirect Cost
Name
Sinai Samaritan Medical Center Milwaukee
Department
Type
DUNS #
City
Milwaukee
State
WI
Country
United States
Zip Code
53201
Siebenlist, K R; Mosesson, M W; Meh, D A et al. (2000) Coexisting dysfibrinogenemia (gammaR275C) and factor V Leiden deficiency associated with thromboembolic disease (fibrinogen Cedar Rapids). Blood Coagul Fibrinolysis 11:293-304
Siebenlist, K R; Meh, D A; Mosesson, M W (2000) Position of gamma-chain carboxy-terminal regions in fibrinogen/fibrin cross-linking mixtures. Biochemistry 39:14171-5
Mosesson, M W; Siebenlist, K R; Voskuilen, M et al. (1998) Evaluation of the factors contributing to fibrin-dependent plasminogen activation. Thromb Haemost 79:796-801
Mosesson, M W; Siebenlist, K R; Meh, D A et al. (1998) The location of the carboxy-terminal region of gamma chains in fibrinogen and fibrin D domains. Proc Natl Acad Sci U S A 95:10511-6
Gailit, J; Clarke, C; Newman, D et al. (1997) Human fibroblasts bind directly to fibrinogen at RGD sites through integrin alpha(v)beta3. Exp Cell Res 232:118-26
Siebenlist, K R; Mosesson, M W (1996) Evidence of intramolecular cross-linked A alpha.gamma chain heterodimers in plasma fibrinogen. Biochemistry 35:5817-21
Mosesson, M W; Siebenlist, K R; Hainfeld, J f et al. (1996) The relationship between the fibrinogen D domain self-association/cross-linking site (gammaXL) and the fibrinogen Dusart abnormality (Aalpha R554C-albumin): clues to thrombophilia in the ""Dusart syndrome"". J Clin Invest 97:2342-50
Siebenlist, K R; Meh, D A; Mosesson, M W (1996) Plasma factor XIII binds specifically to fibrinogen molecules containing gamma chains. Biochemistry 35:10448-53
Meh, D A; Siebenlist, K R; Mosesson, M W (1996) Identification and characterization of the thrombin binding sites on fibrin. J Biol Chem 271:23121-5
Siebenlist, K R; Meh, D A; Wall, J S et al. (1995) Orientation of the carboxy-terminal regions of fibrin gamma chain dimers determined from the crosslinked products formed in mixtures of fibrin, fragment D, and factor XIIIa. Thromb Haemost 74:1113-9

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