Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL047551-03
Application #
2223750
Study Section
General Medicine A Subcommittee 2 (GMA)
Project Start
1993-09-01
Project End
1997-06-30
Budget Start
1995-09-01
Budget End
1997-06-30
Support Year
3
Fiscal Year
1995
Total Cost
Indirect Cost
Name
University of Texas Sw Medical Center Dallas
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
City
Dallas
State
TX
Country
United States
Zip Code
75390
Vasandani, Chandna; Kafrouni, Abdallah I; Caronna, Antonella et al. (2002) Upregulation of hepatic LDL transport by n-3 fatty acids in LDL receptor knockout mice. J Lipid Res 43:772-84
Alam, K; Meidell, R S; Spady, D K (2001) Effect of up-regulating individual steps in the reverse cholesterol transport pathway on reverse cholesterol transport in normolipidemic mice. J Biol Chem 276:15641-9
Spady, D K; Willard, M N; Meidell, R S (2000) Role of acyl-coenzyme A:cholesterol acyltransferase-1 in the control of hepatic very low density lipoprotein secretion and low density lipoprotein receptor expression in the mouse and hamster. J Biol Chem 275:27005-12
Spady, D K; Kearney, D M; Hobbs, H H (1999) Polyunsaturated fatty acids up-regulate hepatic scavenger receptor B1 (SR-BI) expression and HDL cholesteryl ester uptake in the hamster. J Lipid Res 40:1384-94
Spady, D K; Cuthbert, J A; Willard, M N et al. (1998) Overexpression of cholesterol 7alpha-hydroxylase (CYP7A) in mice lacking the low density lipoprotein (LDL) receptor gene. LDL transport and plasma LDL concentrations are reduced. J Biol Chem 273:126-32
Woollett, L A; Spady, D K (1997) Kinetic parameters for high density lipoprotein apoprotein AI and cholesteryl ester transport in the hamster. J Clin Invest 99:1704-13
Woollett, L A; Kearney, D M; Spady, D K (1997) Diet modification alters plasma HDL cholesterol concentrations but not the transport of HDL cholesteryl esters to the liver in the hamster. J Lipid Res 38:2289-302
Spady, D K; Cuthbert, J A; Willard, M N et al. (1996) Feedback regulation of hepatic 7alpha-hydroxylase expression by bile salts in the hamster. J Biol Chem 271:18623-31
Feingold, K R; Spady, D K; Pollock, A S et al. (1996) Endotoxin, TNF, and IL-1 decrease cholesterol 7 alpha-hydroxylase mRNA levels and activity. J Lipid Res 37:223-8
Horton, J D; Cuthbert, J A; Spady, D K (1995) Regulation of hepatic 7 alpha-hydroxylase expression and response to dietary cholesterol in the rat and hamster. J Biol Chem 270:5381-7

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