Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL048916-03
Application #
2225019
Study Section
Pathology A Study Section (PTHA)
Project Start
1993-04-01
Project End
1996-11-30
Budget Start
1995-04-01
Budget End
1996-11-30
Support Year
3
Fiscal Year
1995
Total Cost
Indirect Cost

  Institution

Name
Ohio State University
Department
Miscellaneous
Type
Schools of Engineering
DUNS #
098987217
City
Columbus
State
OH
Country
United States
Zip Code
43210

  Publications

Randolph-Habecker, Julie-Randoph; Rahill, Brian; Torok-Storb, Beverly et al. (2002) The expression of the cytomegalovirus chemokine receptor homolog US28 sequesters biologically active CC chemokines and alters IL-8 production. Cytokine 19:37-46
Froberg, M K; Adams, A; Seacotte, N et al. (2001) Cytomegalovirus infection accelerates inflammation in vascular tissue overexpressing monocyte chemoattractant protein-1. Circ Res 89:1224-30
Moldovan, N I; Goldschmidt-Clermont, P J; Parker-Thornburg, J et al. (2000) Contribution of monocytes/macrophages to compensatory neovascularization: the drilling of metalloelastase-positive tunnels in ischemic myocardium. Circ Res 87:378-84
Crisman, J M; Elder, P J; Wilkie, N M et al. (1999) Identification of amino acids involved in the binding of hMIP-1 alpha to CC-CKR1, a MIP-1 alpha receptor found on neutrophils. Mol Cell Biochem 195:245-56
Beall, C J; Breckenridge, S M; Chakravarty, L et al. (1998) Expression of human monocyte chemoattractant protein-1 in the yeast Pichia pastoris. Protein Expr Purif 12:145-50
Chakravarty, L; Rogers, L; Quach, T et al. (1998) Lysine 58 and histidine 66 at the C-terminal alpha-helix of monocyte chemoattractant protein-1 are essential for glycosaminoglycan binding. J Biol Chem 273:29641-7
Kolattukudy, P E; Quach, T; Bergese, S et al. (1998) Myocarditis induced by targeted expression of the MCP-1 gene in murine cardiac muscle. Am J Pathol 152:101-11
Beall, C J; Mahajan, S; Kuhn, D E et al. (1996) Site-directed mutagenesis of monocyte chemoattractant protein-1 identifies two regions of the polypeptide essential for biological activity. Biochem J 313 ( Pt 2):633-40
Kuhn, D E; Beall, C J; Kolattukudy, P E (1995) The cytomegalovirus US28 protein binds multiple CC chemokines with high affinity. Biochem Biophys Res Commun 211:325-30
Li, Y S; Kolattukudy, P E (1994) Functional role of the cis-acting elements in human monocyte chemotactic protein-1 gene in the regulation of its expression by phorbol ester in human glioblastoma cells. Mol Cell Biochem 141:121-8