Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL049148-02
Application #
2225260
Study Section
Pathology A Study Section (PTHA)
Project Start
1995-05-01
Project End
1998-04-30
Budget Start
1996-05-01
Budget End
1997-04-30
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Wake Forest University Health Sciences
Department
Pathology
Type
Schools of Medicine
DUNS #
041418799
City
Winston-Salem
State
NC
Country
United States
Zip Code
27106
Chen, Bin; Ren, Xuefeng; Neville, Tracey et al. (2009) Apolipoprotein AI tertiary structures determine stability and phospholipid-binding activity of discoidal high-density lipoprotein particles of different sizes. Protein Sci 18:921-35
Ullery-Ricewick, Jody C; Cox, Brian E; Griffin, Evelyn E et al. (2009) Triglyceride alters lysosomal cholesterol ester metabolism in cholesteryl ester-laden macrophage foam cells. J Lipid Res 50:2014-26
Jerome, W Gray; Cox, Brian E; Griffin, Evelyn E et al. (2008) Lysosomal cholesterol accumulation inhibits subsequent hydrolysis of lipoprotein cholesteryl ester. Microsc Microanal 14:138-49
Zhang, Yonghong; Vasudevan, Sheeja; Sojitrawala, Radiya et al. (2007) A monomeric, biologically active, full-length human apolipoprotein E. Biochemistry 46:10722-32
Cox, Brian E; Griffin, Evelyn E; Ullery, Jody C et al. (2007) Effects of cellular cholesterol loading on macrophage foam cell lysosome acidification. J Lipid Res 48:1012-21
Jerome, W Gray (2006) Advanced atherosclerotic foam cell formation has features of an acquired lysosomal storage disorder. Rejuvenation Res 9:245-55
Ren, Xuefeng; Zhao, Lei; Sivashanmugam, Arun et al. (2005) Engineering mouse apolipoprotein A-I into a monomeric, active protein useful for structural determination. Biochemistry 44:14907-19
Griffin, Evelyn E; Ullery, Jody C; Cox, Brian E et al. (2005) Aggregated LDL and lipid dispersions induce lysosomal cholesteryl ester accumulation in macrophage foam cells. J Lipid Res 46:2052-60
Dove, Dwayne E; Su, Yan Ru; Zhang, Wenwu et al. (2005) ACAT1 deficiency disrupts cholesterol efflux and alters cellular morphology in macrophages. Arterioscler Thromb Vasc Biol 25:128-34
Jerome, W Gray; Handt, Stefan; Hantgan, Roy R (2005) Endothelial cells organize fibrin clots into structures that are more resistant to lysis. Microsc Microanal 11:268-77

Showing the most recent 10 out of 20 publications