Regulation of the Activation of Prothrombin

Krishnaswamy, Sriram

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Heart, Lung, and Blood Institute (NHLBI)
• Type: Research Project (R01)
• Project #: 7R01HL052883-05
• Application #: 2750437
• Study Section: Hematology Subcommittee 2 (HEM)
• Project Start: 1994-08-01
• Project End: 1999-07-31
• Budget Start: 1998-04-01
• Budget End: 1998-07-31
• Support Year: 5
• Fiscal Year: 1997

Institution

• Name: Northeastern Mental Health Center
• City: Kendallville
• State: IN
• Country: United States
• Zip Code: 46755

Publications

Boskovic, D S; Krishnaswamy, S (2000) Exosite binding tethers the macromolecular substrate to the prothrombinase complex and directs cleavage at two spatially distinct sites. J Biol Chem 275:38561-70

Betz, A; Krishnaswamy, S (1998) Regions remote from the site of cleavage determine macromolecular substrate recognition by the prothrombinase complex. J Biol Chem 273:10709-18

Krishnaswamy, S; Walker, R K (1997) Contribution of the prothrombin fragment 2 domain to the function of factor Va in the prothrombinase complex. Biochemistry 36:3319-30

Krishnaswamy, S; Betz, A (1997) Exosites determine macromolecular substrate recognition by prothrombinase. Biochemistry 36:12080-6

Betz, A; Vlasuk, G P; Bergum, P W et al. (1997) Selective inhibition of the prothrombinase complex: factor Va alters macromolecular recognition of a tick anticoagulant peptide mutant by factor Xa. Biochemistry 36:181-91

Baugh, R J; Krishnaswamy, S (1996) Role of the activation peptide domain in human factor X activation by the extrinsic Xase complex. J Biol Chem 271:16126-34

Walker, R K; Krishnaswamy, S (1994) The activation of prothrombin by the prothrombinase complex. The contribution of the substrate-membrane interaction to catalysis. J Biol Chem 269:27441-50