Vascular integrity is key to normal function of the organism. While much has recently been learned about factors controlling new vessel growth, maintenance of vascular integrity remains poorly understood. In the previous grant cycle we have demonstrated that FGF signaling plays a key role in maintenance of endothelial cell contacts and that disruption of this signaling leads to disintegration of the mature vasculature. Thus, FGFs appear to play a major, and a totally unexpected, role in this process. In this grant, therefore, we propose to 1) Determine which FGF receptors are involved 2) How this action is achieved. The thorough molecular understanding of this process will likely provide new tools for treatment of vascular diseases, and, potentially, cancer.
In this grant, therefore, we propose to 1) Determine which FGF receptors are involved 2) How this action is achieved. The thorough molecular understanding of this process will likely provide new tools for treatment of vascular diseases, and, potentially, cancer.
|Kofler, Natalie; Simons, Michael (2016) The expanding role of neuropilin: regulation of transforming growth factor-Î² and platelet-derived growth factor signaling in the vasculature. Curr Opin Hematol 23:260-7|
|Chen, Pei-Yu; Qin, Lingfeng; Li, Guangxin et al. (2016) Smooth muscle FGF/TGFÎ² cross talk regulates atherosclerosis progression. EMBO Mol Med 8:712-28|
|Chen, Pei-Yu; Qin, Lingfeng; Li, Guangxin et al. (2016) Fibroblast growth factor (FGF) signaling regulates transforming growth factor beta (TGFÎ²)-dependent smooth muscle cell phenotype modulation. Sci Rep 6:33407|
|Chen, Pei-Yu; Simons, Michael (2016) When endothelial cells go rogue. EMBO Mol Med 8:1-2|
|Deng, Yong; Zhang, Xi; Simons, Michael (2015) Molecular controls of lymphatic VEGFR3 signaling. Arterioscler Thromb Vasc Biol 35:421-9|
|Chen, Pei-Yu; Qin, Lingfeng; Baeyens, Nicolas et al. (2015) Endothelial-to-mesenchymal transition drives atherosclerosis progression. J Clin Invest 125:4514-28|
|Duncan, Daniel R; Chen, Pei-Yu; Patterson, Joseph T et al. (2015) TGFÎ²R1 inhibition blocks the formation of stenosis in tissue-engineered vascular grafts. J Am Coll Cardiol 65:512-4|
|Eelen, Guy; de Zeeuw, Pauline; Simons, Michael et al. (2015) Endothelial cell metabolism in normal and diseased vasculature. Circ Res 116:1231-44|
|Simons, Michael; Eichmann, Anne (2015) Molecular controls of arterial morphogenesis. Circ Res 116:1712-24|
|Chen, Pei-Yu; Qin, Lingfeng; Tellides, George et al. (2014) Fibroblast growth factor receptor 1 is a key inhibitor of TGFÎ² signaling in the endothelium. Sci Signal 7:ra90|
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