Interleukin 8 and Acute Pulmonary Inflammation

Schraufstatter, Ingrid U.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Heart, Lung, and Blood Institute (NHLBI)
• Type: Research Project (R01)
• Project #: 1R01HL055657-01A1
• Application #: 2234272
• Study Section: Lung Biology and Pathology Study Section (LBPA)
• Project Start: 1996-07-01
• Project End: 2000-06-30
• Budget Start: 1996-07-01
• Budget End: 1997-06-30
• Support Year: 1
• Fiscal Year: 1996

Institution

• Name: Scripps Research Institute
• City: La Jolla
• State: CA
• Country: United States
• Zip Code: 92037

Publications

Wimmer, Antonia; Khaldoyanidi, Sophia K; Judex, Martin et al. (2006) CCL18/PARC stimulates hematopoiesis in long-term bone marrow cultures indirectly through its effect on monocytes. Blood 108:3722-9

DiScipio, Richard G; Schraufstatter, Ingrid U; Sikora, Lyudmila et al. (2006) C5a mediates secretion and activation of matrix metalloproteinase 9 from human eosinophils and neutrophils. Int Immunopharmacol 6:1109-18

Zhao, Ming; Discipio, Richard G; Wimmer, Antonia G et al. (2006) Regulation of CXCR4-mediated nuclear translocation of extracellular signal-related kinases 1 and 2. Mol Pharmacol 69:66-75

Burger, Meike; Hartmann, Tanja; Burger, Jan A et al. (2005) KSHV-GPCR and CXCR2 transforming capacity and angiogenic responses are mediated through a JAK2-STAT3-dependent pathway. Oncogene 24:2067-75

Liu-Bryan, Ru; Pay, Salih; Schraufstatter, Ingrid U et al. (2005) The CXCR1 tail mediates beta1 integrin-dependent cell migration via MAP kinase signaling. Biochem Biophys Res Commun 332:117-25

Schraufstatter, Ingrid; Takamori, Hiroshi; Sikora, Lyudmila et al. (2004) Eosinophils and monocytes produce pulmonary and activation-regulated chemokine, which activates cultured monocytes/macrophages. Am J Physiol Lung Cell Mol Physiol 286:L494-501

Zhao, Ming; Wimmer, Antonia; Trieu, Khanh et al. (2004) Arrestin regulates MAPK activation and prevents NADPH oxidase-dependent death of cells expressing CXCR2. J Biol Chem 279:49259-67

Schraufstatter, Ingrid U; Trieu, Khanh; Zhao, Ming et al. (2003) IL-8-mediated cell migration in endothelial cells depends on cathepsin B activity and transactivation of the epidermal growth factor receptor. J Immunol 171:6714-22

Schraufstatter, Ingrid U; Trieu, Khanh; Sikora, Lyudmila et al. (2002) Complement c3a and c5a induce different signal transduction cascades in endothelial cells. J Immunol 169:2102-10

Schraufstatter, I U; Chung, J; Burger, M (2001) IL-8 activates endothelial cell CXCR1 and CXCR2 through Rho and Rac signaling pathways. Am J Physiol Lung Cell Mol Physiol 280:L1094-103