Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
7R01HL056180-02
Application #
2392785
Study Section
Cardiovascular and Pulmonary Research A Study Section (CVA)
Project Start
1996-04-20
Project End
2001-03-31
Budget Start
1997-02-01
Budget End
1997-03-31
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Columbia University (N.Y.)
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
167204994
City
New York
State
NY
Country
United States
Zip Code
10032
Santulli, Gaetano; Pagano, Gennaro; Sardu, Celestino et al. (2015) Calcium release channel RyR2 regulates insulin release and glucose homeostasis. J Clin Invest 125:1968-78
Rullman, Eric; Andersson, Daniel C; Melin, Michael et al. (2013) Modifications of skeletal muscle ryanodine receptor type 1 and exercise intolerance in heart failure. J Heart Lung Transplant 32:925-9
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Andersson, Daniel C; Meli, Albano C; Reiken, Steven et al. (2012) Leaky ryanodine receptors in ýý-sarcoglycan deficient mice: a potential common defect in muscular dystrophy. Skelet Muscle 2:9
Liu, Xiaoping; Betzenhauser, Matthew J; Reiken, Steve et al. (2012) Role of leaky neuronal ryanodine receptors in stress-induced cognitive dysfunction. Cell 150:1055-67
Andersson, Daniel C; Betzenhauser, Matthew J; Reiken, Steven et al. (2012) Stress-induced increase in skeletal muscle force requires protein kinase A phosphorylation of the ryanodine receptor. J Physiol 590:6381-7
Andersson, Daniel C; Betzenhauser, Matthew J; Reiken, Steven et al. (2011) Ryanodine receptor oxidation causes intracellular calcium leak and muscle weakness in aging. Cell Metab 14:196-207
Meli, Albano C; Refaat, Marwan M; Dura, Miroslav et al. (2011) A novel ryanodine receptor mutation linked to sudden death increases sensitivity to cytosolic calcium. Circ Res 109:281-90
Betzenhauser, Matthew J; Marks, Andrew R (2010) Ryanodine receptor channelopathies. Pflugers Arch 460:467-80
Andersson, Daniel C; Marks, Andrew R (2010) Fixing ryanodine receptor Ca leak - a novel therapeutic strategy for contractile failure in heart and skeletal muscle. Drug Discov Today Dis Mech 7:e151-e157

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