by a second class of genes associated with sensory cilia, that are Foxj1-independent.
Specific Aims to test this hypothesis will address: (1) Foxj1-dependent genes to characterize mechanisms of Foxj1 activation for motile assembly and function, and (2) Foxj1-independent sensory cilia genes to investigate their roles in motile cilia assembly and function. Completion of the proposed studies will provide information related to the regulation of mammalian ciliogenesis and open new avenues for examining the evolving role of sensory proteins in airway epithelial cells. Investigation of functions of the ciliated cell will provide new insights into development, differentiation and pathogenesis of airways diseases. Project Description Page 6

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL056244-14
Application #
8197227
Study Section
Lung Cellular, Molecular, and Immunobiology Study Section (LCMI)
Program Officer
Banks-Schlegel, Susan P
Project Start
1997-01-01
Project End
2013-11-30
Budget Start
2011-12-01
Budget End
2013-11-30
Support Year
14
Fiscal Year
2012
Total Cost
$376,200
Indirect Cost
$128,700
Name
Washington University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
068552207
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
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Horani, Amjad; Brody, Steven L; Ferkol, Thomas W (2014) Picking up speed: advances in the genetics of primary ciliary dyskinesia. Pediatr Res 75:158-64
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Horani, Amjad; Ferkol, Thomas W; Shoseyov, David et al. (2013) LRRC6 mutation causes primary ciliary dyskinesia with dynein arm defects. PLoS One 8:e59436
Jain, Raksha; Ray, Jennifer M; Pan, Jie-hong et al. (2012) Sex hormone-dependent regulation of cilia beat frequency in airway epithelium. Am J Respir Cell Mol Biol 46:446-53
Jain, Raksha; Javidan-Nejad, Cylen; Alexander-Brett, Jennifer et al. (2012) Sensory functions of motile cilia and implication for bronchiectasis. Front Biosci (Schol Ed) 4:1088-98
Horani, Amjad; Druley, Todd E; Zariwala, Maimoona A et al. (2012) Whole-exome capture and sequencing identifies HEATR2 mutation as a cause of primary ciliary dyskinesia. Am J Hum Genet 91:685-93

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