Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL060014-08
Application #
6983435
Study Section
Lung Biology and Pathology Study Section (LBPA)
Program Officer
Reynolds, Herbert Y
Project Start
1998-12-01
Project End
2006-11-30
Budget Start
2005-12-01
Budget End
2006-11-30
Support Year
8
Fiscal Year
2006
Total Cost
$332,865
Indirect Cost

  Institution

Name
University of Vermont & St Agric College
Department
Pathology
Type
Schools of Medicine
DUNS #
066811191
City
Burlington
State
VT
Country
United States
Zip Code
05405

  Publications

Qian, Xi; Aboushousha, Reem; van de Wetering, Cheryl et al. (2018) IL-1/inhibitory ?B kinase ?-induced glycolysis augment epithelial effector function and promote allergic airways disease. J Allergy Clin Immunol 142:435-450.e10
Anathy, Vikas; Lahue, Karolyn G; Chapman, David G et al. (2018) Reducing protein oxidation reverses lung fibrosis. Nat Med 24:1128-1135
Heppner, David E; Janssen-Heininger, Yvonne M W; van der Vliet, Albert (2017) The role of sulfenic acids in cellular redox signaling: Reconciling chemical kinetics and molecular detection strategies. Arch Biochem Biophys 616:40-46
Hoffman, Sidra M; Qian, Xi; Nolin, James D et al. (2016) Ablation of Glutaredoxin-1 Modulates House Dust Mite-Induced Allergic Airways Disease in Mice. Am J Respir Cell Mol Biol 55:377-86
Jones, Jane T; Qian, Xi; van der Velden, Jos L J et al. (2016) Glutathione S-transferase pi modulates NF-?B activation and pro-inflammatory responses in lung epithelial cells. Redox Biol 8:375-82
Hristova, Milena; Habibovic, Aida; Veith, Carmen et al. (2016) Airway epithelial dual oxidase 1 mediates allergen-induced IL-33 secretion and activation of type 2 immune responses. J Allergy Clin Immunol 137:1545-1556.e11
Hoffman, Sidra M; Chapman, David G; Lahue, Karolyn G et al. (2016) Protein disulfide isomerase-endoplasmic reticulum resident protein 57 regulates allergen-induced airways inflammation, fibrosis, and hyperresponsiveness. J Allergy Clin Immunol 137:822-32.e7
van der Velden, Jos L J; Ye, Ying; Nolin, James D et al. (2016) JNK inhibition reduces lung remodeling and pulmonary fibrotic systemic markers. Clin Transl Med 5:36
Habibovic, Aida; Hristova, Milena; Heppner, David E et al. (2016) DUOX1 mediates persistent epithelial EGFR activation, mucous cell metaplasia, and airway remodeling during allergic asthma. JCI Insight 1:e88811
Hoffman, Sidra; Nolin, James; McMillan, David et al. (2015) Thiol redox chemistry: role of protein cysteine oxidation and altered redox homeostasis in allergic inflammation and asthma. J Cell Biochem 116:884-92

Showing the most recent 10 out of 64 publications